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Yellow Turmeric Curcuma Longa CurcuminYellow Turmeric Curcuma Longa CurcuminLive Turmeric by the boxload; one Small Flat Rate Box approx 50 rhizomes – Mass Spectrum BotanicalsLive Turmeric by the boxload; one Medium Flat Rate Box approx 400 bulbs – Mass Spectrum BotanicalsLive Turmeric by the boxload; one Large Flat Rate Box approx 750 roots – Mass Spectrum BotanicalsFresh Yellow Turmeric Roots & Whole Black Peppercorns Medicinal Combo KitFresh White Turmeric  (Curcuma zedoaria) Zedaory Roots & Whole Black Peppercorns Medicinal Combo Kit

Gingers, YELLOW TURMERIC (Curcuma longa) Jamaican

$2.00$5,500.00 $2.00$5,500.00

USES: Food / Spice, Medicinal, Ornamental

The Golden Spice: Turmeric is currently being investigated for possible benefits in Alzheimer’s disease, cancer, arthritis, and most other major clinical disorders. It’s main active ingredient is Curcumin, while it and the rest of the family contain many other Curcuminoids which all go together in tandem. The only real flaw is that the body doesn’t absorb them very well, but this is improved significantly by taking it with Black Pepper and by consuming fresh roots (rhizomes) instead of dried root powder.

Read our exhaustive medical reference below. This exclusive guide took a full year to construct, and features over 1000 science links covering over 50 major diseases.

Turmeric orders ship by the Priority Mail Flat Rate box. A Small Flat Rate Box (SFRB) holds about 50 full live rhizomes, while the Medium Flat Rate Box (MFRB) holds about 400 and the Large Flat Rate Box (LFRB) holds about 750. Root piece sizes vary of course. Boxed orders of Live Turmeric wont be dipped in any kind of hormones or chemicals in case the roots are to be eaten. They will ship packed in natural root promoting cocopeat (not pictured), the perfect growth medium for Turmeric.

These food grade live rhizomes (like a bulb) are perfectly edible and can be used to grow live plants. They usually ship packed in natural cocopeat, the perfect substrate to grow them in.

Unlock the true anti-ailment power of Curcuminoids with live root material that contains the fresh essential oils. We’re now offering 1 Cup plastic tubs of whole Black Peppercorns with 1 pound of fresh Turmeric roots. The peppercorns are like tiny little pills very easy to swallow almost without noticing. Slightly crush them before swallowing for maximum effectiveness. Don’t worry the yellow of the roots won’t stain your teeth. Also offering a “Double Turmeric + Pepper Combo” that adds 1 lb. of fresh roots from it’s closest cousin: White Turmeric.

Ordering Options:
2 Live Rhizomes | 15 Live Rhizomes | 1 SFRBox Rhizomes | 1 MFRBox Rhizomes | 1 LFRBox Rhizomes | 1 Root + Black Pepper Combo | 1 Double Turmeric + Pepper Combo | One 6-10″ Live Plant | Five 6-10″ Live Plants | One 10-16″ Live Plant | One 20-30″ Live Plant | 50 Grams Turmeric Powder (Spice) | 1 Lb. Turmeric Powder (Spice) | 4 Lbs. Turmeric Powder (Spice) | 25 Grams 98% Curcumin (YT Extract) | 50 Grams 98% Curcumin (YT Extract) | 100 Grams 98% Curcumin (YT Extract) |  250 Grams 98% Curcumin (YT Extract) |  500 Grams 98% Curcumin (YT Extract) | 1KG 98% Curcumin (YT Extract) | 25KG 98% Curcumin (YT Extract)

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Product Description

YELLOW TURMERIC HORTICULTURAL & MEDICINAL GUIDE

v1.0 Last Updated: 3-09-14
Brought to you by Mass Spectrum Botanicals

Curcuma longa is an herbaceous tropical root crop plant with short-stemmed long broad leaves reaching up to 3-4’ each. It forms a main core rhizome that sends off finger like secondary rhizomes up to about 6” long. The raw inner flesh looks very similar to that of an orange carrot. It’s quite obvious in most forms to be a close relative to the ginger family, but likewise a distinct tribe. The raw rhizomes have a characteristic odor, a slightly bitter almost pungent taste. If eaten whole and raw it makes the mouth kind of numb, without being ‘hot’. The cured and dried rhizome produce an aromatic yellow-orange powder that is used as a spice, a coloring agent and for extract products. As a spice it has versatile uses in rice, curry powders, and in processed foods & sauces. As a color it is used as a textile dye, and as a coloring agent in pharmacy & food industries. The oleoresin is used in processed food and it also has potent multiple-disease medicinal properties.

Of 110 species of the genus Curcuma L., only about 20 species have been studied phytochemically. Curcuma longa is the most chemically investigated species of Curcuma. To date, at least 235 compounds, primarily phenolic compounds and terpenoids have been identified, including diarylheptanoids (including commonly known as curcuminoids), diarylpentanoids, monoterpenes, sesquiterpenes, diterpenes, triterpenoids, alkaloid, and sterols, etc. The main active components are Cucuminoids (3-15%) and essential oils (1.5-5%). Turmeric extracts or the active curcuminoids have also shown neuroprotective, nootropic, hepatoprotective, cardioprotective, hypoglycemic (anti-diabetic), anti-amyloidogenic, antimicrobial, antifungal, parasiticidal, antioxidant, anti-tumor, larvicidal, chemo-resistance and radio-resistance activities.

Some insights into growing Yellow Turmeric (Curcuma longa):

Turmeric cannot be grown as a houseplant, unless it regularly gets over 80°F and has full sun most of the day in your home. This plant thrives in bright, wet, heat. In Central Florida, when the night time averages start dropping below 70°F growth tends to slow. As the total average temperature dials down, and the day-night temperature differential gap widens with increasing consistency, the leaves will yellow and start dying back. The root portions will stay perfectly alive until next Spring when they decide to begin. While the actively growing plat love lots of water, don’t over water dormant roots as any sort of measure to make them grow or you might make them rot out instead.

Some insights into sprouting Yellow Turmeric (Curcuma longa):

Despite some studies claiming it’s best to plant rhizomes 4-6” deep, we’ve had the best results getting new growth during the colder months (when the the big old plantings are dormant) by loading them into standard seedling flats that are only 2” deep. 100% Coconut Coir (cocopeat) is the ideal substrate. Having them in a line of similar trays all getting warm and keeping the temperature stabilized is important for ideal results. Another good technique learned last year is instead placing them in similar shallow fashion in small aquariums. During the Winter this year, a lot of the old small leftover rhizomes in it rotted, yet there remained green plants sprouting all the way through our mild Winter.

Some insights into harvesting Yellow Turmeric (Curcuma longa):

Turmeric is best harvested once per year, during dormancy, assuming the entire plant mass is to be uprooted. Here we wait until Spring just before around the time we’d expect it to have a chance to start re-growing. When left together, we find the rhizome mass perfectly intact, although many of the associated ‘roots’ will be mostly dead. Each ‘individual plant’ will have a gnarly mass of fingerling rhizomes attached to a semi-cone shaped central root. The core root resembles a ‘top’ (spinning toy). These core roots are never sold as commercial culinary produce. The fingers should be collected and the core roots re-planted.

Some insights into re-growing Yellow Turmeric (Curcuma longa):

Dipping the core roots into various plant biostimulants, replanting them surrounded by cocopeat, and/or amending the soil with nitrate dominant fertilizer should help increase re-growth rates. The fingers can be grown into new plants, of course. If being able to harvest pieces throughout the year is a goal, it should be possible by planting them in giant containers deep with 100% loose substrate (cocopeat & perlite). If the plants go dormant in your area, then this probably shouldn’t be attempted until midway through the following season, having left most of the root masses alone during dormancy. A late spring PGR / biostimulant substrate treatment should send the old fingerling roots into a topside vegetative growth fury. After a month or so usable root pieces should be plentiful. Growing them in cocopeat will help them grow well, especially in the beginning, and will stay lose so that root pieces can be removed without much bothering the plant masses themselves. If a greenhouse type shelter can be provided for them during cold months to maintain green growth, then having to wait an extra season to begin the perpetual harvest might be unnecessary.

Dietary sources of Turmeric / Curcumin:

Turmeric root, Turmeric spice powder, yellow curry powders / pastes, yellow mustard condiment and “indian saffron” spice.

Notes on Curcuminoid bioavailability (absorb-ability) in the human body:

While curcuminoids are very effective against many types of cancer and many other ailments, but they are hydrophobic (repels from water) and the the body doesn’t absorb them internally so well. Supplementing with black pepper along side the curcumin helps with this. Some recent research suggests that the use of fresh plant material containing the raw essential oils is more effective in the human body than high purity dry curcumin products alone.

Known Curcuminoid Synergists:

With liver cancer, Resveratrol has been documented to have synergistic effects when combined with Curcumin1. Turmeric synergistically works with Phenethyl Isothiocyanates (found in Broccoli family vegetables) to halt prostate cancer1. Turmeric and Quercetin (found in onions) shrink colon cancer polyps1. Turmeric is documented to work synergistically with numerous pharmaceutical chemotherapy drugs, in many cases overcoming resistance to the drugs the tumors had proven before adding Turmeric into the treatment (see many examples in the below sections)

Chemical Constituents (Non-oils)*:

Curcumin [10%]; Demetoksikurkumin [5%]; Anlatone; Bisdemetoksikurkumin; Curcuminoids [many others]; fat 1-3%; 3% carbohydrate; protein 30%; 8% starch; 45-55% of vitamin C; mineral salts (iron, phosphorus & calcium).

Chemical constituents of various tissues of turmeric (Curcuma longa L.)

At least 235 compounds, primarily phenolic compounds and terpenoids have been identified from the species, including 22 diarylheptanoids and diarylpentanoids, eight phenylpropene and other phenolic compounds, 68 monoterpenes, 109 sesquiterpenes, five diterpenes, three triterpenoids, four sterols, two alkaloids, and 14 other compounds. Curcuminoids in turmeric are primarily accumulated in rhizomes. The essential oils from leaves and flowers are usually dominated by monoterpenes while those from roots and rhizomes primarily contained sesquiterpenes. The contents of curcuminoids in turmeric rhizomes vary often with varieties, locations, sources, and cultivation conditions, while there are significant variations in composition of essential oils of turmeric rhizomes with varieties and geographical locations. Further, both curcuminoids and essential oils vary in contents with different extraction methods and are unstable with extraction and storage processes. As a result, the quality of commercial turmeric products can be markedly varied. Curcumin, demethoxycurcumin, and bisdemethoxycurcumin have been used as marker compounds for the quality control of rhizomes, powders, and extract (“curcumin”) products.

Yellow Turmeric Culinary Data Links:

Yellow Turmeric Research Data Links:

Crescent Bloom – Curcumin Analogue Development Tracker – Dave’s Garden – Extension – Google Scholar – Mass Spectrum Botanicals – Mr. Ginseng – National Tropical Botanical Garden – PubMed – Rainforest Garden – Sacred Earth – Sigma Aldrich – USDA – Wikipedia – Youtube

 

Turmeric (Vitamin T) Vs. World Disease

Brought to you by Mass Spectrum Botanicals

PubMed.gov was the source for the following 1,000+ published science links. Just “curcumin” has over 6,000 PubMed results, so there are many more papers that go with these. PubMed abstracts are typically brief, while many of these papers can be viewed online in their full versions if you go looking for them. The vast majority of this link set are specific to Curcuma longa chemical constituents. Early in the construction of this page it was decided to omit all papers pertaining to the even more promising nano, derivative or synthetic analogs to the core natural curcuminoids. Of the 110 species in the genus Curcuma, only about 20 have been studied. There was a directive to not include papers for Curcuminoids only found in other Curcuma species, but a few might have slipped through. About 90% of all of the links in this entire manuscript are studies done during only the past 10 years.  The point is that the core set of studied Curcuminoids are essentially single handedly beating down to the raw bones of the fists at the premise that plants can’t produce real world medicine, and lots of it. Plenty of, if not most, plants have some constituent, at least, that can do great good for at least some ailment, that is currently demonstrated via study. Yet here the core Curcuminoid class chems (found only in the Curcuma genus) are flanking and smashing to pieces dozens of different disease fronts simultaneously. Meanwhile, the full potential of Curcuminoid class chems and their various potential derivatives are only just beginning to be realized. The world finally catching on to the power of this genus and its unique family of chemicals is truly an epic in modern chemistry. This looming saga shouldn’t go unnoticed.

  1. Therapeutic roles of curcumin: lessons learned from clinical trials.
  2. Early human safety study of turmeric oil (Curcuma longa oil) administered orally in healthy volunteers.
  3. Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs.
  4. Curcumin and curcumin-like molecules: from spice to drugs.
  5. Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature.
  6. Role of curcumin in health and disease.
  7. Safety and pharmacokinetics of a solid lipid curcumin particle formulation in osteosarcoma patients and healthy volunteers.
  8. Plant-derived health: the effects of turmeric and curcuminoids.
  9. “Spicing up” of the immune system by curcumin.
  10. Suppression of the nuclear factor-kappaB activation pathway by spice-derived phytochemicals: reasoning for seasoning.
  11. Discovery of curcumin, a component of golden spice, and its miraculous biological activities.

Turmeric vs. Alcohol-Induced Disease

  1. Curcumin ameliorates ethanol-induced memory deficits and enhanced brain nitric oxide synthase activity in mice.
  2. Anti-fatty liver effects of oils from Zingiber officinale and Curcuma longa on ethanol-induced fatty liver in rats.
  3. Comparative effects of curcumin and its analog on alcohol- and polyunsaturated fatty acid-induced alterations in circulatory lipid profiles.
  4. Protective Role of a Novel Curcuminoid on Alcohol and PUFA-Induced Hyperlipidemia.
  5. Curcumin prevents chronic alcohol-induced liver disease involving decreasing ROS generation and enhancing antioxidative capacity.
  6. Long-term ethanol exposure-induced hepatocellular carcinoma cell migration and invasion through lysyl oxidase activation are attenuated by combined treatment with pterostilbene and curcumin analogues.
  7. Curcumin, an atoxic antioxidant and natural NFkappaB, cyclooxygenase-2, lipooxygenase, and inducible nitric oxide synthase inhibitor: a shield against acute and chronic diseases.
  8. Effect of curcumin on the increase in hepatic or brain phosphatidylcholine hydroperoxide levels in mice after consumption of excessive alcohol.
  9. Attenuation of oxidative stress, neuroinflammation, and apoptosis by curcumin prevents cognitive deficits in rats postnatally exposed to ethanol.
  10. The effect of coenzyme Q10 and curcumin on chronic methanol intoxication induced retinopathy in rats.
  11. Dietary agents in the prevention of alcohol-induced hepatotoxicty: preclinical observations.
  12. Low doses of curcumin protect alcohol-induced liver damage by modulation of the alcohol metabolic pathway, CYP2E1 and AMPK.
  13. Inhibition of histone acetylation by curcumin reduces alcohol-induced expression of heart development-related transcription factors in cardiac progenitor cells.
  14. Negative effects of curcumin on liver injury induced by alcohol.
  15. Therapeutic role of curcumin in prevention of biochemical and behavioral aberration induced by alcoholic neuropathy in laboratory animals.
  16. Curcumin alleviates ethanol-induced hepatocytes oxidative damage involving heme oxygenase-1 induction.
  17. Curcumin decreased oxidative stress, inhibited NF-kappaB activation, and improved liver pathology in ethanol-induced liver injury in rats.
  18. Curcumin attenuates ethanol-induced toxicity in HT22 hippocampal cells by activating mitogen-activated protein kinase phosphatase-1.
  19. Curcumin protects Leydig cells of mice from damage induced by chronic alcohol administration.
  20. Effects of curcumin on ethanol-induced hepatocyte necrosis and apoptosis: implication of lipid peroxidation and cytochrome c.
  21. The effect of curcumin on ethanol induced changes in suprachiasmatic nucleus (SCN) and pineal.
  22. Curcumin combats against cigarette smoke and ethanol-induced lipid alterations in rat lung and liver.

Turmeric vs. Alzheimer’s Disease:

  1. The effect of curcumin (turmeric) on Alzheimer’s disease: An overview.
  2. Effects of turmeric on Alzheimer’s disease with behavioral and psychological symptoms of dementia.
  3. Curcuminoids and resveratrol as anti-Alzheimer agents.
  4. Curcumin-conjugated nanoliposomes with high affinity for Aβ deposits: Possible applications to Alzheimer disease.
  5. Na(+) -K(+) -ATPase, a potent neuroprotective modulator against Alzheimer disease.
  6. Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people.
  7. A plant cell-based system that predicts aβ42 misfolding: potential as a drug discovery tool for Alzheimer’s disease.
  8. Dietary polyphenol-derived protection against neurotoxic β-amyloid protein: from molecular to clinical.
  9. Natural products as a rich source of tau-targeting drugs for Alzheimer’s disease.
  10. Activation of α-secretase by curcumin-aminoacid conjugates.
  11. From BACE1 inhibitor to multifunctionality of tryptoline and tryptamine triazole derivatives for Alzheimer’s disease.
  12. The effect of curcumin on the stability of Aβ dimers.
  13. Pleiotropic protective effects of phytochemicals in Alzheimer’s disease.
  14. Inhibitory effect of curcumin on the Al(III)-induced Aβ₄₂ aggregation and neurotoxicity in vitro.
  15. Curcumin-conjugated nanoliposomes with high affinity for Aβ deposits: Possible applications to Alzheimer disease.
  16. Neuroprotective and neurorescue effects of a novel polymeric nanoparticle formulation of curcumin (NanoCurc™) in the neuronal cell culture and animal model: implications for Alzheimer’s disease.
  17. Oxidative stress and Alzheimer’s disease: dietary polyphenols as potential therapeutic agents.
  18. Amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of Alzheimer’s type (SDAT).
  19. A novel neurotrophic drug for cognitive enhancement and Alzheimer’s disease.
  20. MORE

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Turmeric vs. Arsenic Poisoning:

  1. Curcumin Protects Human Keratinocytes against Inorganic Arsenite-Induced Acute Cytotoxicity through an NRF2-Dependent Mechanism.
  2. Curcumin encapsulated in chitosan nanoparticles: a novel strategy for the treatment of arsenic toxicity.
  3. Protective effect of curcumin against arsenic-induced apoptosis in murine splenocytes in vitro.
  4. Neuroprotective efficacy of curcumin in arsenic induced cholinergic dysfunctions in rats.
  5. Curcumin prevents DNA damage and enhances the repair potential in a chronically arsenic-exposed human population in West Bengal, India.
  6. Indian spice curcumin may be an effective strategy to combat the genotoxicity of arsenic in Swiss albino mice.
  7. Curcumin and turmeric attenuate arsenic-induced angiogenesis in ovo.
  8. Curcumin supplementation protects from genotoxic effects of arsenic and fluoride.
  9. Curcumin protects DNA damage in a chronically arsenic-exposed population of West Bengal.
  10. A Mechanistic Approach for Modulation of Arsenic Toxicity in Human Lymphocytes by Curcumin, an Active Constituent of Medicinal Herb Curcuma longa Linn.

Turmeric vs. Arthritis:

  1. Curcumin: a new paradigm and therapeutic opportunity for the treatment of osteoarthritis: curcumin for osteoarthritis management.
  2. Curcumin potentiates the anti-arthritic effect of prednisolone in Freund’s complete adjuvant-induced arthritic rats.
  3. Curcumin in inflammatory diseases.
  4. Curcumin protects against collagen-induced arthritis via suppression of BAFF production.
  5. Dietary polyphenols and mechanisms of osteoarthritis.
  6. A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis.
  7. The efficacy of Curcuma Longa L. extract as an adjuvant therapy in primary knee osteoarthritis: a randomized control trial.
  8. Synergistic activity of curcumin with methotrexate in ameliorating Freund’s Complete Adjuvant induced arthritis with reduced hepatotoxicity in experimental animals.
  9. Oral administration of curcumin suppresses production of matrix metalloproteinase (MMP)-1 and MMP-3 to ameliorate collagen-induced arthritis: inhibition of the PKCdelta/JNK/c-Jun pathway.
  10. Interleukin-1beta-induced extracellular matrix degradation and glycosaminoglycan release is inhibited by curcumin in an explant model of cartilage inflammation.
  11. Curcumin induces apoptosis and inhibits prostaglandin E(2) production in synovial fibroblasts of patients with rheumatoid arthritis.
  12. The antioxidants curcumin and quercetin inhibit inflammatory processes associated with arthritis.
  13. Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis.
  14. Curcumin synergistically potentiates the growth-inhibitory and pro-apoptotic effects of celecoxib in osteoarthritis synovial adherent cells.
  15. Presence of an acidic glycoprotein in the serum of arthritic rats: modulation by capsaicin and curcumin.

Turmeric vs. Asthma:

  1. Curcumin alone and in combination with augmentin protects against pulmonary inflammation and acute lung injury generated during Klebsiella pneumoniae B5055-induced lung infection in BALB/c mice.
  2. Curcumin inhibits the proliferation of airway smooth muscle cells in vitro and in vivo.
  3. Curcumin attenuates allergic airway inflammation by regulation of CD4+CD25+ regulatory T cells (Tregs)/Th17 balance in ovalbumin-sensitized mice.
  4. Curcumin suppresses ovalbumin-induced allergic conjunctivitis.
  5. Anti-inflammatory effects of curcumin in a murine model of chronic asthma.
  6. Oral curcumin supplementation in patients with atopic asthma.
  7. Curcumin attenuates allergic airway inflammation and hyper-responsiveness in mice through NF-κB inhibition.
  8. Immunomodulatory effects of curcumin in allergy.
  9. Curcumin attenuates allergen-induced airway hyperresponsiveness in sensitized guinea pigs.
  10. Curcumin inhibition of Dermatophagoides farinea-induced interleukin-5 (IL-5) and granulocyte macrophage-colony stimulating factor (GM-CSF) production by lymphocytes from bronchial asthmatics.

Turmeric vs. Brain Damage / Disorders:

  1. Anticonvulsive and antioxidant effects of curcumin on pilocarpine-induced seizures in rats.
  2. Botanical phenolics and brain health.
  3. Neuroprotective efficacy and therapeutic window of curcuma oil: in rat embolic stroke model.
  4. Dose dependence and therapeutic window for the neuroprotective effects of curcumin in thromboembolic model of rat.
  5. Curcuma oil modulates the nitric oxide system response to cerebral ischemia/reperfusion injury.
  6. Protective effect of Curcumin, the active principle of turmeric (Curcuma longa) in haloperidol-induced orofacial dyskinesia and associated behavioural, biochemical and neurochemical changes in rat brain.
  7. Curcumin suppresses soluble tau dimers and corrects molecular chaperone, synaptic, and behavioral deficits in aged human tau transgenic mice.
  8. Neuronal uptake and neuroprotective effect of curcumin-loaded PLGA nanoparticles on the human SK-N-SH cell line.
  9. Curcumin-glucoside, a novel synthetic derivative of curcumin, inhibits α-synuclein oligomer formation: relevance to Parkinson’s disease.
  10. A novel neurotrophic drug for cognitive enhancement and Alzheimer’s disease.
  11. Redox regulation of cellular stress response in neurodegenerative disorders.
  12. Mitochondrial dysfunction, free radical generation and cellular stress response in neurodegenerative disorders.
  13. Effects of Curcuma phaeocaulis on learning and memory and lipid peroxide in mice].
  14. Curcumin attenuates peroxynitrite-induced neurotoxicity in spiral ganglion neurons.
  15. Protective effects of curcumin against lithium-pilocarpine induced status epilepticus, cognitive dysfunction and oxidative stress in young rats.
  16. Neuroprotection by curcumin in ischemic brain injury involves the Akt/Nrf2 pathway.
  17. Ameliorative effect of Curcumin on seizure severity, depression like behavior, learning and memory deficit in post-pentylenetetrazole-kindled mice.
  18. Curcumin prevents mitochondrial dysfunction in the brain of the senescence-accelerated mouse-prone 8.
  19. Piperine potentiates the protective effects of curcumin against chronic unpredictable stress-induced cognitive impairment and oxidative damage in mice.
  20. Attenuation of oxidative stress, neuroinflammation, and apoptosis by curcumin prevents cognitive deficits in rats postnatally exposed to ethanol.
  21. Neuroprotective effect of α-mangostin and curcumin against iodoacetate-induced cell death.
  22. Curcuminoids in neurodegenerative diseases.
  23. Beneficial effects of curcumin on GFAP filament organization and down-regulation of GFAP expression in an in vitro model of Alexander disease.
  24. Curcumin restores Nrf2 levels and prevents quinolinic acid-induced neurotoxicity.
  25. Curcumin protects against cigarette smoke-induced cognitive impairment and increased acetylcholinesterase activity in rats.
  26. Improvement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington’s disease.
  27. Effect of curcumin in a mouse model of Pelizaeus-Merzbacher disease.
  28. Neuroprotection and sensorimotor functional improvement by curcumin after intracerebral hemorrhage in mice.
  29. MORE

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Turmeric vs. Cancer (Overview):

  1. Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs.
  2. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions.
  3. Cancer chemopreventive effects of curcumin.
  4. Biological effects of curcumin and its role in cancer chemoprevention and therapy.
  5. Mechanisms of cancer chemoprevention by curcumin.
  6. Recent studies on the biofunctions and biotransformations of curcumin.
  7. Anaphase-promoting complex/cyclosome protein Cdc27 is a target for curcumin-induced cell cycle arrest and apoptosis.
  8. Curcumin induces radiosensitivity of in vitro and in vivo cancer models by modulating pre-mRNA processing factor 4 (Prp4).
  9. Anticancer and carcinogenic properties of curcumin: considerations for its clinical development as a cancer chemopreventive and chemotherapeutic agent.
  10. Radioprotection and radiosensitization by curcumin.
  11. Effect of curcumin on normal and tumor cells: role of glutathione and bcl-2.
  12. Protection of radiation-induced protein damage by curcumin.
  13. Anti-tumour and antioxidant activity of natural curcuminoids.
  14. Curcumin and cancer: an “old-age” disease with an “age-old” solution.
  15. Multi-targeted therapy by curcumin: how spicy is it?
  16. Potential anticancer activity of turmeric (Curcuma longa).
  17. Cancer chemopreventive effects of curcumin.
  18. Curcumin: the Indian solid gold.
  19. Cancer prevention by antioxidants.
  20. Biologic evaluation of curcumin and structural derivatives in cancer chemoprevention model systems.
  21. Mechanisms of cancer chemoprevention by curcumin.
  22. Combinatorial antitumor effect of naringenin and curcumin elicit angioinhibitory activities in vivo.
  23. Synergistic anticancer activity of curcumin and catechin: an in vitro study using human cancer cell lines.
  24. Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines.
  25. Cancer stem cells: potential target for bioactive food components.
  26. Curcumin as an inhibitor of cancer.
  27. Curcumin in cancer chemoprevention: molecular targets, pharmacokinetics, bioavailability, and clinical trials.
  28. Curcumin as an anti-cancer agent: review of the gap between basic and clinical applications.
  29. Plant-derived anticancer agents – curcumin in cancer prevention and treatment.

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Turmeric vs. Cancer (Bile Duct):

  1. Curcumin Prevents Bile Canalicular Alterations in the Liver of Hamsters Infected with Opisthorchis viverrini.
  2. Biliary excretion of curcumin is mediated by multidrug resistance-associated protein 2.
  3. Anticancer activities against cholangiocarcinoma, toxicity and pharmacological activities of Thai medicinal plants in animal models.
  4. Curcumin suppresses proliferation and induces apoptosis in human biliary cancer cells through modulation of multiple cell signaling pathways.
  5. Curcumin analog GO-Y030 is a novel inhibitor of IKKβ that suppresses NF-κB signaling and induces apoptosis.
  6. Curcumin decreases cholangiocarcinogenesis in hamsters by suppressing inflammation-mediated molecular events related to multistep carcinogenesis.
  7. Redox modulation and human bile duct cancer inhibition by curcumin.
  8. Reduction of periductal fibrosis in liver fluke-infected hamsters after long-term curcumin treatment.
  9. Curcumin reduces oxidative and nitrative DNA damage through balancing of oxidant-antioxidant status in hamsters infected with Opisthorchis viverrini.

Turmeric vs. Cancer (Bladder):

  1. Knockdown of Ki-67 by dicer-substrate small interfering RNA sensitizes bladder cancer cells to curcumin-induced tumor inhibition.
  2. Curcumin-induced heme oxygenase-1 expression plays a negative role for its anti-cancer effect in bladder cancers.
  3. Curcumin-induced mitotic spindle defect and cell cycle arrest in human bladder cancer cells occurs partly through inhibition of aurora A.
  4. Activation of muscarinic M-1 cholinoceptors by curcumin to increase contractility in urinary bladder isolated from Wistar rats.
  5. Curcumin potentiates the antitumor effects of Bacillus Calmette-Guerin against bladder cancer through the downregulation of NF-kappaB and upregulation of TRAIL receptors.
  6. Effects of curcumin in an orthotopic murine bladder tumor model.
  7. Curcumin potentiates the antitumor effects of gemcitabine in an orthotopic model of human bladder cancer through suppression of proliferative and angiogenic biomarkers.
  8. Curcumin decreases specificity protein expression in bladder cancer cells.
  9. Effects of curcumin on bladder cancer cells and development of urothelial tumors in a rat bladder carcinogenesis model.
  10. Sensitivity of bladder cancer cells to curcumin and its derivatives depends on the extracellular matrix.
  11. Curcumin potentiates the apoptotic effects of chemotherapeutic agents and cytokines through down-regulation of nuclear factor-kappaB and nuclear factor-kappaB-regulated gene products in IFN-alpha-sensitive and IFN-alpha-resistant human bladder cancer cells.
  12. Induction of G2/M arrest and inhibition of cyclooxygenase-2 activity by curcumin in human bladder cancer T24 cells.
  13. Apoptosis-inducing effects of curcumin derivatives in human bladder cancer cells.
  14. The effect of curcumin on bladder cancer cell line EJ in vitro].
  15. Curcumin, but not Prima-1, decreased tumor cell proliferation in the syngeneic murine orthotopic bladder tumor model.

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Turmeric vs. Cancer (Bone Marrow):

  1. The influence of curcumin and (-)-epicatechin on the genotoxicity and myelosuppression induced by etoposide in bone marrow cells of male rats.
  2. Myelopotentiating effect of curcumin in tumor-bearing host: role of bone marrow resident macrophages.

Osteosarcoma:

  1. Cytotoxic effects of curcumin on osteosarcoma cell lines.
  2. Curcumin induces cell cycle arrest and apoptosis in human osteosarcoma (HOS) cells.
  3. Short communication: selective cytotoxicity of curcumin on osteosarcoma cells compared to healthy osteoblasts.
  4. The Combined Effect of Encapsulating Curcumin and C6 Ceramide in Liposomal Nanoparticles against Osteosarcoma.
  5. Reversion effects of curcumin on multidrug resistance of MNNG/HOS human osteosarcoma cells in vitro and in vivo through regulation of P-glycoprotein.
  6. Curcumin induces osteosarcoma MG63 cells apoptosis via ROS/Cyto-C/Caspase-3 pathway.
  7. Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells.
  8. Curcumin inhibits proliferation and invasion of osteosarcoma cells through inactivation of Notch-1 signaling.
  9. Selective cytotoxicity against human osteosarcoma cells by a novel synthetic C-1 analogue of 7-deoxypancratistatin is potentiated by curcumin.
  10. Resveratrol and diallyl disulfide enhance curcumin-induced sarcoma cell apoptosis.
  11. Empirical study of reverse effect on mediated multidrug resistance of U-2OS/ADM cells with curcumin in vitro].
  12. The aberrant expressions of nuclear matrix proteins during the apoptosis of human osteosarcoma cells.
  13. Antitumor activity of natural compounds, curcumin and PKF118-310, as Wnt/β-catenin antagonists against human osteosarcoma cells.
  14. Apoptotic effects of curcumin on human osteosarcoma U2OS cells.
  15. Changes of nuclear matrix proteins during apoptosis of human osteosarcoma MG-63 cells induced by curcumin].

Multiple Myeloma:

  1. Curcumin Enhances Cytotoxic Effects of Bortezomib in Human Multiple Myeloma H929 Cells: Potential Roles of NF-κB/JNK.
  2. Monoclonal gammopathy of undetermined significance, smoldering multiple myeloma, and curcumin: a randomized, double-blind placebo-controlled cross-over 4g study and an open-label 8g extension study.
  3. Effect of curcumin in combination with bortezomib on proliferation and apoptosis of human multiple myeloma cell line H929 and its mechanism].
  4. Synergistic apoptotic effect of arabinoxylan rice bran (MGN-3/Biobran) and curcumin (turmeric) on human multiple myeloma cell line U266 in vitro.
  5. Reversal of multidrug resistance by curcumin through FA/BRCA pathway in multiple myeloma cell line MOLP-2/R.
  6. Curcumin in combination with bortezomib synergistically induced apoptosis in human multiple myeloma U266 cells.
  7. Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model.
  8. Effect of curcumin on expression of survivin, Bcl-2 and Bax in human multiple myeloma cell line].
  9. Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells.
  10. Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis.

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Turmeric vs. Cancer (Brain):

  1. Curcumin Blocks Brain Tumor Formation.
  2. An investigation of the ability of elemene to pass through the blood-brain barrier and its effect on brain carcinomas.
  3. Curcumin and its derivatives: their application in neuropharmacology and neuroscience in the 21st century.
  4. DAPK1 modulates a curcumin-induced G2/M arrest and apoptosis by regulating STAT3, NF-κB, and caspase-3 activation.
  5. Curcumin inhibits telomerase and induces telomere shortening and apoptosis in brain tumour cells.
  6. Potentiation of etoposide and temozolomide cytotoxicity by curcumin and turmeric force™ in braintumor cell lines.
  7. Β-elemene inhibits Hsp90/Raf-1 molecular complex inducing apoptosis of glioblastoma cells.
  8. β-elemene inhibits proliferation of human glioblastoma cells through the activation of glia maturation factor β and induces sensitization to cisplatin.
  9. ß-Elemene inhibits proliferation of human glioblastoma cells and causes cell-cycle G0/G1 arrest via mutually compensatory activation of MKK3 and MKK6.
  10. An investigation of the ability of elemene to pass through the blood-brain barrier and its effect on brain carcinomas.
  11. Curcuma oil: reduces early accumulation of oxidative product and is anti-apoptogenic in transient focal ischemia in rat brain.
  12. Curcumin suppressed anti-apoptotic signals and activated cysteine proteases for apoptosis in human malignant glioblastoma U87MG cells.
  13. Preliminary experience with personalized and targeted therapy for pediatric brain tumors.
  14. Dendrosomal curcumin nanoformulation downregulates pluripotency genes via miR-145 activation in U87MG glioblastoma cells.
  15. Epigenetic reactivation of RANK in glioblastoma cells by curcumin: involvement of STAT3 inhibition.
  16. Antiglioma activity of curcumin-loaded lipid nanoparticles and its enhanced bioavailability in brain tissue for effective glioblastoma therapy.
  17. Curcumin promotes differentiation of glioma-initiating cells by inducing autophagy.
  18. The curry spice curcumin selectively inhibits cancer cells growth in vitro and in preclinical model of glioblastoma.
  19. The nontoxic natural compound Curcumin exerts anti-proliferative, anti-migratory, and anti-invasive properties against malignant gliomas.
  20. Curcuminoids suppress the growth and induce apoptosis through caspase-3-dependent pathways in glioblastoma multiforme (GBM) 8401 cells.
  21. The anti-cancer efficacy of curcumin scrutinized through core signaling pathways in glioblastoma.
  22. Curcumin inhibits tumor growth and angiogenesis in glioblastoma xenografts.
  23. Curcumin suppresses growth and chemoresistance of human glioblastoma cells via AP-1 and NFkappaB transcription factors.
  24. Curcumin suppressed anti-apoptotic signals and activated cysteine proteases for apoptosis in human malignant glioblastoma U87MG cells.
  25. Curcumin activated both receptor-mediated and mitochondria-mediated proteolytic pathways for apoptosis in human glioblastoma T98G cells.

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Turmeric vs. Cancer (Breast):

  1. Antiproliferative effect of an analog of curcumin bis-1,7-(2-hydroxyphenyl)-hepta-1,6-diene-3,5-dione in human breast cancer cells.
  2. Antitumor activity and antioxidant property of Curcuma caesia against Ehrlich’s ascites carcinoma bearing mice.
  3. BreastDefend™ prevents breast-to-lung cancer metastases in an orthotopic animal model of triple-negative human breast cancer.
  4. Induction of human breast cell carcinogenesis by triclocarban and intervention by curcumin.
  5. Curcumin induces apoptosis in a murine mammary gland adenocarcinoma cell line through the mitochondrial pathway.
  6. Anti-breast cancer activity of curcumin on the human oxidation-resistant cells ZR-75-1 with gamma-glutamyltranspeptidase inhibition.
  7. Dietary curcumin inhibits chemotherapy-induced apoptosis in models of human breast cancer.
  8. Inhibition of invasion and induction of apoptosis by curcumin in H-ras-transformed MCF10A human breast epithelial cells.
  9. Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients.
  10. Curcumin induces apoptosis in breast cancer cell lines and delays the growth of mammary tumors in neu transgenic mice.
  11. The cellular uptake and cytotoxic effect of curcuminoids on breast cancer cells.
  12. Dimethoxycurcumin-induced cell death in human breast carcinoma MCF7 cells: evidence for pro-oxidant activity, mitochondrial dysfunction, and apoptosis.
  13. Curcumin inhibits metastatic progression of breast cancer cell through suppression of urokinase-type plasminogen activator by NF-kappa B signaling pathways.
  14. Curcumin decreases survival of Hep3B liver and MCF-7 breast cancer cells: the role of HIF.
  15. Curcumin enhances the efficacy of chemotherapy by tailoring p65NFκB-p300 cross-talk in favor of p53-p300 in breast cancer.
  16. Curcumin inhibits proliferation of breast cancer cells through Nrf2-mediated down-regulation of Fen1 expression.
  17. miR181b is induced by the chemopreventive polyphenol curcumin and inhibits breast cancer metastasis via down-regulation of the inflammatory cytokines CXCL1 and -2.
  18. Curcumin Reduces Cytotoxicity of 5-Fluorouracil Treatment in Human Breast Cancer Cells.
  19. PAMAM dendrimers augment inhibitory effects of curcumin on cancer cell proliferation: possible inhibition of telomerase.
  20. Curcumin Targets Breast Cancer Stem-like Cells with Microtentacles That Persist in Mammospheres and Promote Reattachment.
  21. Mechanism of apoptotic induction in human breast cancer cell, MCF-7, by an analog of curcumin in comparison with curcumin – An in vitro and in silico approach.
  22. Potentiation of paclitaxel activity by curcumin in human breast cancer cell by modulating apoptosis and inhibiting EGFR signaling.
  23. Curcumin suppresses doxorubicin-induced epithelial-mesenchymal transition via the inhibition of TGF-β and PI3K/AKT signaling pathways in triple-negative breast cancer cells.
  24. Immunoliposome encapsulation increases cytotoxic activity and selectivity of curcumin and resveratrol against HER2 overexpressing human breast cancer cells.
  25. Mutant p53-Notch1 Signaling Axis Is Involved in Curcumin-Induced Apoptosis of Breast Cancer Cells.
  26. Curcumin enhances TRAIL-induced apoptosis of breast cancer cells by regulating apoptosis-related proteins.
  27. The effect of curcumin on breast cancer cells.
  28. Curcumin triggers p16-dependent senescence in active breast cancer-associated fibroblasts and suppresses their paracrine procarcinogenic effects.
  29. Tumor necrosis factor alpha induces Warburg-like metabolism and is reversed by anti-inflammatory curcumin in breast epithelial cells.
  30. MORE

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Turmeric vs. Cancer (Carcinoma):

  1. Curcuminoid binding to embryonal carcinoma cells: reductive metabolism, induction of apoptosis, senescence, and inhibition of cell proliferation.
  2. Comparison of the effects of curcumin and curcumin glucuronide in human hepatocellular carcinoma HepG2 cells.
  3. Curcumin enhances the radiosensitivity in nasopharyngeal carcinoma cells involving the reversal of differentially expressed long non-coding RNAs.
  4. Curcumin inhibited hypoxia induced epithelial-mesenchymal transition in hepatic carcinoma cell line HepG2 in vitro].
  5. Inhibition of specificity protein 1 by dibenzylideneacetone, a curcumin analogue, induces apoptosis in mucoepidermoid carcinomas and tumor xenografts through Bim and truncated Bid.
  6. Targeting different angiogenic pathways with combination of curcumin, leflunomide and perindopril inhibits diethylnitrosamine-induced hepatocellular carcinoma in mice.
  7. Curcumin enhances the effectiveness of cisplatin by suppressing CD133<sup>+</sup> cancer stem cells in laryngeal carcinoma treatment.
  8. Chemoprevention of head and neck squamous cell carcinoma through inhibition of NF-κB signaling.
  9. Study on functions and mechanism of curcumin in inducing colorectal carcinoma cells LoVo apoptosis].
  10. Curcumin suppresses proliferation and induces apoptosis of human hepatocellular carcinoma cells via the wnt signaling pathway.
  11. Differential anti-tumor activities of curcumin against Ras- and Src-activated human adenocarcinoma cells.
  12. Curcuminoid binding to embryonal carcinoma cells: reductive metabolism, induction of apoptosis, senescence, and inhibition of cell proliferation.

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Turmeric vs. Cancer (Cervical):

  1. The chemopreventive agent curcumin is a potent radiosensitizer of human cervical tumor cells via increased reactive oxygen species production and overactivation of the mitogen-activated protein kinase pathway.
  2. Molecular evidences for the chemosensitizing efficacy of liposomal curcumin in paclitaxel chemotherapy in mouse models of cervical cancer.
  3. Influence of curcumin-loaded cationic liposome on anticancer activity for cervical cancer therapy.
  4. Effects of NF-kappaB inhibitor on cisplatin-induced apoptosis in cervical cancer].
  5. A novel curcumin-based vaginal cream Vacurin selectively eliminates apposed human cervical cancer cells.
  6. Chemopreventive and chemotherapeutic potential of curcumin in breast cancer.
  7. Curcumin counteracts the proliferative effect of estradiol and induces apoptosis in cervical cancer cells.
  8. Molecular mechanism of curcumin induced cytotoxicity in human cervical carcinoma cells.
  9. Constitutive activation of transcription factor AP-1 in cervical cancer and suppression of human papillomavirus (HPV) transcription and AP-1 activity in HeLa cells by curcumin.
  10. Modulation of P-glycoprotein expression and function by curcumin in multidrug-resistant human KB cells.

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Turmeric vs. Cancer (Colon):

  1. Curcumin combined with turmerones, essential oil components of turmeric, abolishes inflammation-associated mouse colon carcinogenesis.
  2. Curcumin induces apoptosis in human colorectal carcinoma (HCT-15) cells by regulating expression of Prp4 and p53.
  3. TF/FVIIa/PAR2 promotes cell proliferation and migration via PKCα and ERK-dependent c-Jun/AP-1 pathway in colon cancer cell line SW620.
  4. Citrus limonoids and curcumin additively inhibit human colon cancer cells.
  5. Down-regulation of miR-21 Induces Differentiation of Chemoresistant Colon Cancer Cells and Enhances Susceptibility to Therapeutic Regimens.
  6. Molecular mechanisms of chemopreventive phytochemicals against gastroenterological cancer development.
  7. Curcumin modulates DNA methylation in colorectal cancer cells.
  8. Curcumin enhances the effect of chemotherapy against colorectal cancer cells by inhibition of NF-κB and Src protein kinase signaling pathways.
  9. Synergistic anticancer effects of curcumin and resveratrol in Hepa1-6 hepatocellular carcinoma cells.
  10. Carnitines slow down tumor development of colon cancer in the DMH-chemical carcinogenesis mouse model.
  11. bis-dehydroxy-curcumin triggers mitochondrial-associated cell death in human colon cancer cells through ER-stress induced autophagy.
  12. Effects of hexahydrocurcumin in combination with 5-fluorouracil on dimethylhydrazine-induced colon cancer in rats.
  13. Curcumin and docosahexaenoic acid block insulin-induced colon carcinoma cell proliferation.
  14. Native and β-cyclodextrin-enclosed curcumin: entrapment within liposomes and their in vitro cytotoxicity in lung and colon cancer.
  15. Interaction of over-the-counter drugs with curcumin: influence on stability and bioactivities in intestinal cells.
  16. Arene-Ru(II) Complexes of Curcumin Exert Antitumor Activity via Proteasome Inhibition and Apoptosis Induction.
  17. Chemoprevention of azoxymethane-initiated colon cancer in rat by using a novel polymeric nanocarrier–curcumin.
  18. Hexahydrocurcumin enhances inhibitory effect of 5-fluorouracil on HT-29 human colon cancer cells.
  19. Chemoprevention with phytonutrients and microalgae products in chronic inflammation and colon cancer.
  20. Curcumin induces permanent growth arrest of human colon cancer cells: link between senescence and autophagy.
  21. Curcumin synergizes with resveratrol to inhibit colon cancer.
  22. Diphenyl difluoroketone: a curcumin derivative with potent in vivo anticancer activity.
  23. Curcumin enhances the effects of 5-fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF-1R.
  24. Celecoxib and curcumin synergistically inhibit the growth of colorectal cancer cells.
  25. Anti-proliferation and anti-angiogenesis of curcumin-K30 solid dispersion.
  26. Cell apoptosis induced by delta-elemene in colorectal adenocarcinoma cells via a mitochondrial-mediated pathway.
  27. Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent, during the promotion/progression stages of colon cancer.
  28. Curcumin induces apoptosis in human colorectal carcinoma (HCT-15) cells by regulating expression of Prp4 and p53.
  29. Curcumin-induced apoptosis of human colon cancer colo 205 cells through the production of ROS, Ca2+ and the activation of caspase-3.
  30. Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations.
  31. The effect of curcumin and placebo on human gall-bladder function: an ultrasound study.
  32. MORE

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Turmeric vs. Cancer (Gallbladder):

  1. Curcumin induces apoptosis in gallbladder carcinoma cell line GBC-SD cells.
  2. Antiproliferative and apoptosis-inducing activity of curcumin against human gallbladder adenocarcinoma cells.
  3. Advances in clinical study of curcumin.
  4. Effect of different curcumin dosages on human gall bladder.

Turmeric vs. Cancer (Gastric):

  1. Curcumin induces apoptosis in human gastric carcinoma AGS cells and colon carcinoma HT-29 cells through mitochondrial dysfunction and endoplasmic reticulum stress.
  2. Study on functions and mechanism of curcumin in inducing gastric carcinoma BGC apoptosis].
  3. Curcumin combined FOLFOX induced cell apoptosis of gastric cancer and its mechanism research].
  4. Inhibitory effects of curcumin on gastric cancer cells: a proteomic study of molecular targets.
  5. Curcumin attenuates gastric cancer induced by N-methyl-N-nitrosourea and saturated sodium chloride in rats.
  6. Study on functions and mechanism of curcumin in inducing gastric carcinoma BGC apoptosis].
  7. Curcumin reverses chemoresistance of human gastric cancer cells by downregulating the NF-κB transcription factor.
  8. Curcumin induces the differentiation of myeloid-derived suppressor cells and inhibits their interaction with cancer cells and related tumor growth.
  9. Curcumin suppresses proliferation and invasion in human gastric cancer cells by downregulation of PAK1 activity and cyclin D1 expression.
  10. Effect of curcumin on multidrug resistance in resistant human gastric carcinoma cell line SGC7901/VCR.
  11. Curcumin inhibits the growth of AGS human gastric carcinoma cells in vitro and shows synergism with 5-fluorouracil.
  12. Curcumin induced modulation of cell cycle and apoptosis in gastric and colon cancer cells.
  13. Mechanism of inhibition of benzo[a]pyrene-induced forestomach cancer in mice by dietary curcumin.
  14. Adjuvant chemoprevention of experimental cancer: catechin and dietary turmeric in forestomach and oral cancer models.

Turmeric vs. Cancer (Head & Neck):

  1. Curcumin treatment suppresses IKKβ kinase activity of salivary cells of patients with head and neck cancer: a pilot study.
  2. Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma.
  3. Curcumin enhances the effect of cisplatin in suppression of head and neck squamous cell carcinoma via inhibition of IKKβ protein of the NFκB pathway.
  4. Chemopreventive potential of natural compounds in head and neck cancer.
  5. Curcumin inhibits carcinogen and nicotine-induced Mammalian target of rapamycin pathway activation in head and neck squamous cell carcinoma.
  6. Chemoprevention of head and neck squamous cell carcinoma through inhibition of NF-κB signaling.
  7. Curcumin and other polyphenolic compounds in head and neck cancer chemoprevention.
  8. Anti-cancer effects of curcumin on head and neck cancers.
  9. Curcumin: a potential radio-enhancer in head and neck cancer.
  10. Suppression of interleukin 6 and 8 production in head and neck cancer cells with curcumin via inhibition of Ikappa beta kinase.
  11. Moving toward bioadjuvant approaches to head and neck cancer prevention.
  12. Targeting constitutive and interleukin-6-inducible signal transducers and activators of transcription 3 pathway in head and neck squamous cell carcinoma cells by curcumin (diferuloylmethane).
  13. Curcumin suppresses growth of head and neck squamous cell carcinoma.
  14. Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappaB signaling.
  15. Curcumin treatment alters ERK-1/2 signaling in vitro and inhibits nasopharyngeal carcinoma proliferation in mouse xenografts.

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Turmeric vs. Cancer (Leukemia):

  1. Induction of apoptosis by curcumin in murine myelomonocytic leukemia WEHI-3 cells is mediated via endoplasmic reticulum stress and mitochondria-dependent pathways.
  2. Induction of apoptosis in murine leukemia by diarylheptanoids from Curcuma comosa Roxb.
  3. β-Elemene piperazine derivatives induce apoptosis in human leukemia cells through downregulation of c-FLIP and generation of ROS.
  4. Curcumin-induced cell cycle arrest and apoptosis in human acute promyelocytic leukemia HL-60 cells via MMP changes and caspase-3 activation.
  5. Curcumin potentiates antitumor activity of L-asparaginase via inhibition of the AKT signaling pathway in acute lymphoblastic leukemia.
  6. Curcumin suppresses constitutive activation of AP-1 by downregulation of JunD protein in HTLV-1-infected T-cell lines.
  7. Curcumin (diferuloylmethane) inhibits constitutive active NF-kappaB, leading to suppression of cell growth of human T-cell leukemia virus type I-infected T-cell lines and primary adult T-cell leukemia cells.
  8. Effect of curcumin combined with ATRA on differentiation of ATRA-resistant acute promyelocytic leukemia cells].
  9. Curcumin down-regulates DNA methyltransferase 1 and plays an anti-leukemic role in acute myeloid leukemia.
  10. Potential role of curcumin and taurine combination therapy on human myeloid leukemic cells propagated in vitro.
  11. Anti-tumor effect of tanshinone II A, tetrandrine, honokiol, curcumin, oridonin and paeonol on leukemia cell lines].
  12. Pure curcumin decreases the expression of WT1 by upregulation of miR-15a and miR-16-1 in leukemic cells.
  13. Curcumin induces the apoptosis of human monocytic leukemia THP-1 cells via the activation of JNK/ERK pathways.
  14. Glutathione regulates caspase-dependent ceramide production and curcumin-induced apoptosis in human leukemic cells.
  15. Curcumin blocks Kv11.1 (erg) potassium current and slows proliferation in the infant acute monocytic leukemia cell line THP-1.
  16. Tetrahydrocurcumin, a major metabolite of curcumin, induced autophagic cell death through coordinative modulation of PI3K/Akt-mTOR and MAPK signaling pathways in human leukemia HL-60 cells.
  17. Curcumin sensitizes acute promyelocytic leukemia cells to unfolded protein response-induced apoptosis by blocking the loss of misfolded N-CoR protein.
  18. Curcumin reduces expression of Bcl-2, leading to apoptosis in daunorubicin-insensitive CD34+ acute myeloid leukemia cell lines and primary sorted CD34+ acute myeloid leukemia cells.
  19. Investigation of the apoptotic effect of curcumin in human leukemia HL-60 cells by using flow cytometry.
  20. Distinct combinatorial effects of the plant polyphenols curcumin, carnosic acid, and silibinin on proliferation and apoptosis in acute myeloid leukemia cells.
  21. Curcumin stimulates reactive oxygen species production and potentiates apoptosis induction by the antitumor drugs arsenic trioxide and lonidamine in human myeloid leukemia cell lines.
  22. Curcumin p38-dependently enhances the anticancer activity of valproic acid in human leukemia cells.
  23. Cytotoxic activity of curcumin towards CCRF-CEM leukemia cells and its effect on DNA damage.
  24. Effect of curcumin on nuclear factor kappaB signaling pathways in human chronic myelogenous K562 leukemia cells.
  25. Rapamycin and curcumin induce apoptosis in primary resting B chronic lymphocytic leukemia cells.
  26. Induction of heat shock response by curcumin in human leukemia cells.
  27. Turmeric and green tea: a recipe for the treatment of B-chronic lymphocytic leukemia.
  28. Curcumin inhibits prosurvival pathways in chronic lymphocytic leukemia B cells and may overcome their stromal protection in combination with EGCG.
  29. Selective killing of leukemia and lymphoma cells ectopically expressing hCGbeta by a conjugate of curcumin with an antibody against hCGbeta subunit.
  30. Curcumin inhibits WEHI-3 leukemia cells in BALB/c mice in vivo.
  31. Cytotoxic effects of curcumin on osteosarcoma cell lines.
  32. Effect of pure curcumin, demethoxycurcumin, and bisdemethoxycurcumin on WT1 gene expression in leukemic cell lines.

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Turmeric vs. Cancer (Liver):

  1. Inhibitory effects of Curcuma aromatica oil on proliferation of hepatoma in mice.
  2. In vivo study on the effects of curcumin on the expression profiles of anti-tumour genes (VEGF, CyclinD1 and CDK4) in liver of rats injected with DEN.
  3. Mechanism study on anti-proliferative effects of curcumol in human hepatocarcinoma HepG2 cells].
  4. Curcuma increasing antitumor effect of Rhizoma paridis saponins through absorptive enhancement of paridis saponins.
  5. Curcumin induces apoptosis of HepG2 cells via inhibiting fatty acid synthase.
  6. Synergistic anticancer effects of curcumin and resveratrol in Hepa1-6 hepatocellular carcinoma cells.
  7. Anti-tumor effect of germacrone on human hepatoma cell lines through inducing G2/M cell cycle arrest and promoting apoptosis.
  8. Supercritical carbon dioxide extraction of aromatic turmerone from Curcuma longa Linn. induces apoptosis through reactive oxygen species-triggered intrinsic and extrinsic pathways in human hepatocellular carcinoma HepG2 cells.
  9. Curcumin induces apoptosis involving bax/bcl-2 in human hepatoma SMMC-7721 cells.
  10. Potential chemoprevention of diethylnitrosamine-induced hepatocarcinogenesis in rats: myrrh (Commiphora molmol) vs. turmeric (Curcuma longa).
  11. Curcumin and liver cancer: a review.
  12. Chemopreventive effect of Curcuma longa Linn on liver pathology in HBx transgenic mice.
  13. Curcumin inhibits the proliferation of human hepatocellular carcinoma J5 cells by inducing endoplasmic reticulum stress and mitochondrial dysfunction.
  14. Curcumin decreases cholangiocarcinogenesis in hamsters by suppressing inflammation-mediated molecular events related to multistep carcinogenesis.
  15. Inhibitory effects of curcumenol on human liver cytochrome P450 enzymes.
  16. Effect of curcumin on JAK-STAT signaling pathway in hepatoma cell lines].
  17. Professor Ling Changquan’s experience in treating primary liver cancer: an analysis of herbal medication].
  18. Essential oil of Curcuma wenyujin induces apoptosis in human hepatoma cells.
  19. Inhibition of curcumin on histone deacetylase and expression promotion of P21 (WAF1/CIP1) in HepG2 cells].
  20. Furanodiene induces G2/M cell cycle arrest and apoptosis through MAPK signaling and mitochondria-caspase pathway in human hepatocellular carcinoma cells.
  21. Regulation of p53-, Bcl-2- and caspase-dependent signaling pathway in xanthorrhizol-induced apoptosis of HepG2 hepatoma cells.
  22. Chemopreventive effects of embelin and curcumin against N-nitrosodiethylamine/phenobarbital-induced hepatocarcinogenesis in Wistar rats.
  23. Curcumin inhibits ROS formation and apoptosis in methylglyoxal-treated human hepatoma G2 cells.
  24. Inhibition of nitrosodiethylamine-induced hepatocarcinogenesis by dietary turmeric in rats.
  25. A controlled clinical study between hepatic arterial infusion with embolized curcuma aromatic oil and chemical drugs in treating primary liver cancer].
  26. Inhibition by curcumin of diethylnitrosamine-induced hepatic hyperplasia, inflammation, cellular gene products and cell-cycle-related proteins in rats.
  27. Therapeutic efficacy of microsphere-entrapped curcuma aromatica oil infused via hepatic artery against transplanted hepatoma in rats].
  28. NTP Toxicology and Carcinogenesis Studies of Turmeric Oleoresin (CAS No. 8024-37-1) (Major Component 79%-85% Curcumin, CAS No. 458-37-7) in F344/N Rats and B6C3F1 Mice (Feed Studies).
  29. Reversal of aflatoxin induced liver damage by turmeric and curcumin.
  30. Protective role of aqueous turmeric extract against mutagenicity of direct-acting carcinogens as well as benzo [alpha] pyrene-induced genotoxicity and carcinogenicity.
  31. Potential chemoprevention of diethylnitrosamine-induced hepatocarcinogenesis in rats: myrrh (Commiphora molmol) vs. turmeric (Curcuma longa).
  32. Anti-cancer and anti-angiogenic effects of curcumin and tetrahydrocurcumin on implanted hepatocellular carcinoma in nude mice.
  33. MicroRNA-200a/b influenced the therapeutic effects of curcumin in hepatocellular carcinoma (HCC) cells.

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Turmeric vs. Cancer (Lung):

  1. Curcumin reverses cis-platin resistance and promotes human lung adenocarcinoma A549/DDP cell apoptosis through HIF-1α and caspase-3 mechanisms.
  2. Synergistic antitumor efficiency of docetaxel and curcumin against lung cancer.
  3. Effects of curcumin on N-bis(2-hydroxypropyl) nitrosamine (DHPN)-induced lung and liver tumorigenesis in BALB/c mice in vivo.
  4. Curcumin reverses cis-platin resistance and promotes human lung adenocarcinoma A549/DDP cell apoptosis through HIF-1α and caspase-3 mechanisms.
  5. Curcumin induces small cell lung cancer NCI-H446 cell apoptosis via the reactive oxygen species-mediated mitochondrial pathway and not the cell death receptor pathway.
  6. Curcumin sensitizes non-small cell lung cancer cell anoikis through reactive oxygen species-mediated Bcl-2 downregulation.
  7. DNA damage and endoplasmic reticulum stress mediated curcumin-induced cell cycle arrest and apoptosis in human lung carcinoma A-549 cells through the activation caspases cascade- and mitochondrial-dependent pathway.
  8. Activation of apoptotic protein in U937 cells by a component of turmeric oil.
  9. Developing curcumin into a viable therapeutic for lymphoma.
  10. Curcumin lowers erlotinib resistance in non-small cell lung carcinoma cells with mutated EGF receptor.
  11. Diarylheptanoids from the bark of black alder inhibit the growth of sensitive and multi-drug resistant non-small cell lung carcinoma cells.
  12. Curcumin sensitizes lung adenocarcinoma cells to apoptosis via intracellular redox status mediated pathway.
  13. Dietary supplementation with curcumin enhances metastatic growth of Lewis lung carcinoma in mice.
  14. A systemic administration of liposomal curcumin inhibits radiation pneumonitis and sensitizes lung carcinoma to radiation.
  15. Curcumin blocks small cell lung cancer cells migration, invasion, angiogenesis, cell cycle and neoplasia through Janus kinase-STAT3 signalling pathway.
  16. Curcumin inhibits tumor proliferation induced by neutrophil elastase through the upregulation of α1-antitrypsin in lung cancer.
  17. Curcumin reverses cis-platin resistance and promotes human lung adenocarcinoma A549/DDP cell apoptosis through HIF-1α and caspase-3 mechanisms.
  18. Properties of lewis lung carcinoma cells surviving curcumin toxicity.
  19. Synergistic antitumor efficiency of docetaxel and curcumin against lung cancer.
  20. Lysosomal membrane permeabilization is involved in curcumin-induced apoptosis of A549 lung carcinoma cells.
  21. Curcumin enhances the mitomycin C-induced cytotoxicity via downregulation of MKK1/2-ERK1/2-mediated Rad51 expression in non-small cell lung cancer cells.
  22. Combined treatment of curcumin and small molecule inhibitors suppresses proliferation of A549 and H1299 human non-small-cell lung cancer cells.
  23. Hypomethylation effects of curcumin, demethoxycurcumin and bisdemethoxycurcumin on WIF-1 promoter in non-small cell lung cancer cell lines.
  24. MORE

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Turmeric vs. Cancer (Lymphoma):

  1. Curcumin suppresses constitutive activation of nuclear factor-kappa B and requires functional Bax to induce apoptosis in Burkitt’s lymphoma cell lines.
  2. Curcumin improves the antitumor effect of X-ray irradiation by blocking the NF-κB pathway: an in-vitro study of lymphoma.
  3. Curcumin induces apoptosis and inhibits growth of human Burkitt’s lymphoma in xenograft mouse model.
  4. Anti-tumor activity of four Ayurvedic herbs in Dalton lymphoma ascites bearing mice and their short-term in vitro cytotoxicity on DLA-cell-line.
  5. Spleen tyrosine kinase (Syk), a novel target of curcumin, is required for B lymphoma growth.
  6. Curcumin suppresses growth and induces apoptosis in primary effusion lymphoma.
  7. Effect of curcumin on caspase 8- and caspase 9- induced apoptosis of lymphoma Raji cell].
  8. Alkylphosphocholines and curcumin induce programmed cell death in cutaneous T-cell lymphoma cell lines.
  9. Curcumin selectively induces apoptosis in cutaneous T-cell lymphoma cell lines and patients’ PBMCs: potential role for STAT-3 and NF-kappaB signaling.
  10. Jak3- and JNK-dependent vascular endothelial growth factor expression in cutaneous T-cell lymphoma.

Turmeric vs. Cancer (Ocular):

  1. Effect of curcumin on miRNA expression in human Y79 retinoblastoma cells.
  2. Curcumin induces cell death in human uveal melanoma cells through mitochondrial pathway.
  3. Inhibition of tumor growth and vasculogenic mimicry by curcumin through down-regulation of the EphA2/PI3K/MMP pathway in a murine choroidal melanoma model.
  4. Effect of curcumin on lung resistance-related protein (LRP) in retinoblastoma cells.
  5. Modulation of multidrug resistance 1 expression and function in retinoblastoma cells by curcumin.
  6. In vitro and In silico studies on inhibitory effects of curcumin on multi drug resistance associated protein (MRP1) in retinoblastoma cells.
  7. Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation.

Turmeric vs. Cancer (Oral / Throat):

  1. Xanthorrhizol induces apoptosis through ROS-mediated MAPK activation in human oral squamous cell carcinoma cells and inhibits DMBA-induced oral carcinogenesis in hamsters.
  2. Adjuvant chemoprevention of experimental cancer: catechin and dietary turmeric in forestomach and oral cancer models.
  3. Curcumin-induced autophagy contributes to the decreased survival of oral cancer cells.
  4. Curcumin upregulates insulin-like growth factor binding protein-5 (IGFBP-5) and C/EBPalpha during oral cancer suppression.
  5. Curcumin synergistically enhances the radiosensitivity of human oral squamous cell carcinoma via suppression of radiation-induced NF-κB activity.
  6. Curcumin targets fibroblast-tumor cell interactions in oral squamous cell carcinoma.
  7. Nutraceuticals as new treatment approaches for oral cancer–I: Curcumin.
  8. Synergic effect of curcumin or lycopene with irradiation upon oral squamous cell carcinoma cells.
  9. Effects of curcumin on stem-like cells in human esophageal squamous carcinoma cell lines.
  10. Curcumin potentiates the antitumor effects of 5-FU in treatment of esophageal squamous carcinoma cells through downregulating the activation of NF-κB signaling pathway in vitro and in vivo.
  11. Curcumin inhibits tongue carcinoma cells migration and invasion through downregulation of matrix metallopeptidase 10.
  12. Comparison of the effect of p65 siRNA and curcumin in promoting apoptosis in esophageal squamous cell carcinoma cells and in nude mice.
  13. Curcumin abrogates bile-induced NF-κB activity and DNA damage in vitro and suppresses NF-κB activity whilst promoting apoptosis in vivo, suggesting chemopreventative potential in Barrett’s oesophagus.
  14. Induction of apoptotic death by curcumin in human tongue squamous cell carcinoma SCC-4 cells is mediated through endoplasmic reticulum stress and mitochondria-dependent pathways.
  15. Anti-proliferative and anti-metastatic effects of curcumin on oral cancer cells].
  16. Inhibitory effect of curcumin on oral carcinoma CAL-27 cells via suppression of Notch-1 and NF-κB signaling pathways.
  17. Effect of curcumin and irradiation in PE/CA-PJ15 oral squamous cell carcinoma.
  18. Effect of preparation techniques on the properties of curcumin liposomes: characterization of size, release and cytotoxicity on a squamous oral carcinoma cell line.
  19. Curcumin inhibits tongue carcinoma cells migration and invasion through downregulation of matrix metallopeptidase 10.
  20. MORE

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Turmeric vs. Cancer (Ovarian):

  1. Growth-inhibitory effects of curcumin on ovary cancer cells and its mechanisms.
  2. Curcumin attenuates EGF-induced AQP3 up-regulation and cell migration in human ovarian cancer cells.
  3. Pro-apoptotic effects of curcumin associated with CIK cells against ovarian carcinoma cells].
  4. A novel mono-carbonyl analogue of curcumin induces apoptosis in ovarian carcinoma cells via endoplasmic reticulum stress and reactive oxygen species production.
  5. Combined effects of curcumin and triptolide on an ovarian cancer cell line.
  6. Synergistic interaction of Paclitaxel and curcumin with cyclodextrin polymer complexation in human cancer cells.
  7. Pro-apoptotic effects of curcumin associated with CIK cells against ovarian carcinoma cells].
  8. Reversing paclitaxel-resistance of SKOV3-TR30 cell line by curcumin].
  9. Study on curcumin-induced apoptosis in ovarian cancer resistant cell lines COC1/DDP].
  10. HO-3867, a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1-mutated ovarian cancer cells.
  11. Sphingosine kinase-1 inhibition sensitizes curcumin-induced growth inhibition and apoptosis in ovarian cancer cells.
  12. Advances in the treatment of ovarian cancer: a potential role of antiinflammatory phytochemicals.
  13. Synergism from the combination of oxaliplatin with selected phytochemicals in human ovarian cancer cell lines.
  14. Synergism from sequenced combinations of curcumin and epigallocatechin-3-gallate with cisplatin in the killing of human ovarian cancer cells.
  15. Curcumin induces chemo/radio-sensitization in ovarian cancer cells and curcumin nanoparticles inhibit ovarian cancer cell growth.
  16. Curcumin suppresses constitutive activation of STAT-3 by up-regulating protein inhibitor of activated STAT-3 (PIAS-3) in ovarian and endometrial cancer cells.
  17. Curcumin-induced apoptosis in ovarian carcinoma cells is p53-independent and involves p38 mitogen-activated protein kinase activation and downregulation of Bcl-2 and survivin expression and Akt signaling.
  18. Cell-cycle inhibition and apoptosis induced by curcumin and cisplatin or oxaliplatin in human ovarian carcinoma cells.
  19. Curcumin attenuates EGF-induced AQP3 up-regulation and cell migration in human ovarian cancer cells.
  20. Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factor-kappaB pathway.
  21. Curcumin enhances Apo2L/TRAIL-induced apoptosis in chemoresistant ovarian cancer cells.
  22. Inhibitory effects of curcumin on apoptosis of human ovary cancer cell line A2780 and its molecular mechanism].

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Turmeric vs. Cancer (Pancreatic):

  1. Polyethylene glycosylated curcumin conjugate inhibits pancreatic cancer cell growth through inactivation of Jab1.
  2. Novel curcumin-loaded magnetic nanoparticles for pancreatic cancer treatment.
  3. Curcumin and gemcitabine in patients with advanced pancreatic cancer.
  4. A phase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer.
  5. Curcumin inhibits tumor growth and angiogenesis in an orthotopic mouse model of human pancreatic cancer.
  6. Efficacy of liposomal curcumin in a human pancreatic tumor xenograft model: inhibition of tumor growth and angiogenesis.
  7. Curcumin reverses the epithelial-mesenchymal transition of pancreatic cancer cells by inhibiting the Hedgehog signaling pathway.
  8. A phase I study investigating the safety and pharmacokinetics of highly bioavailable curcumin (Theracurmin) in cancer patients.
  9. The molecular mechanism of action of aspirin, curcumin and sulforaphane combinations in the chemoprevention of pancreatic cancer.
  10. Synergistic effect of garcinol and curcumin on antiproliferative and apoptotic activity in pancreatic cancer cells.
  11. Impact of curcumin, raspberry extract, and neem leaf extract on rel protein-regulated cell death/radiosensitization in pancreatic cancer cells.
  12. RNA binding protein CUGBP2/CELF2 mediates curcumin-induced mitotic catastrophe of pancreatic cancer cells.
  13. Modulatory effects of curcumin on multi-drug resistance-associated protein 5 in pancreatic cancer cells.
  14. A phase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer.
  15. Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation.
  16. Potentiation of gemcitabine by Turmeric Force in pancreatic cancer cell lines.
  17. Gemcitabine sensitivity can be induced in pancreatic cancer cells through modulation of miR-200 and miR-21 expression by curcumin or its analogue CDF.
  18. Curcumin inhibits constitutive STAT3 phosphorylation in human pancreatic cancer cell lines and downregulation of survivin/BIRC5 gene expression.
  19. Prevention and treatment of pancreatic cancer by curcumin in combination with omega-3 fatty acids.
  20. Synergistic effects of multiple natural products in pancreatic cancer cells.
  21. Phase II trial of curcumin in patients with advanced pancreatic cancer.
  22. Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells.
  23. Curcumin augments gemcitabine cytotoxic effect on pancreatic adenocarcinoma cell lines.
  24. Curcumin for chemoprevention of colon cancer.
  25. Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells.
  26. Curcumin synergistically potentiates the growth inhibitory and pro-apoptotic effects of celecoxib in pancreatic adenocarcinoma cells.
  27. Nuclear factor-kappaB and IkappaB kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis.
  28. Curcumin inhibits interleukin 8 production and enhances interleukin 8 receptor expression on the cell surface:impact on human pancreatic carcinoma cell growth by autocrine regulation.

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Turmeric vs. Cancer (Pituitary):

  1. Curcumin suppresses HIF1A synthesis and VEGFA release in pituitary adenomas.
  2. Curcumin inhibits the growth, induces apoptosis and modulates the function of pituitary folliculostellate cells.
  3. Curcumin acts as anti-tumorigenic and hormone-suppressive agent in murine and human pituitary tumour cells in vitro and in vivo.
  4. Growth suppression of mouse pituitary corticotroph tumor AtT20 cells by curcumin: a model for treating Cushing’s disease.
  5. Curcumin (diferuloylmethane) inhibits cell proliferation, induces apoptosis, and decreases hormone levels and secretion in pituitary tumor cells.

Turmeric vs. Cancer (Prostate):

  1. Early human safety study of turmeric oil (Curcuma longa oil) administered orally in healthy volunteers.
  2. Curcumin confers radiosensitizing effect in prostate cancer cell line PC-3.
  3. A monocarbonyl analogue of curcumin, 1,5-bis(3-hydroxyphenyl)-1,4-pentadiene-3-one (Ca 37), exhibits potent growth suppressive activity and enhances the inhibitory effect of curcumin on human prostate cancer cells.
  4. Curcumin inhibits prostate cancer metastasis in vivo by targeting the inflammatory cytokines CXCL1 and -2.
  5. Curcumin provides potential protection against the activation of hypoxia and prolyl 4-hydroxylase inhibitors on prostate-specific antigen expression in human prostate carcinoma cells.
  6. Recent progress on nutraceutical research in prostate cancer.
  7. Curcumin-targeting pericellular serine protease matriptase role in suppression of prostate cancer cell invasion, tumor growth, and metastasis.
  8. Curcumin inhibits prostate cancer metastasis in vivo by targeting the inflammatory cytokines CXCL1 and -2.
  9. Curcumin attenuates β-catenin signaling in prostate cancer cells through activation of protein kinase D1.
  10. Anti-tumor activity of curcumin against androgen-independent prostate cancer cells via inhibition of NF-κB and AP-1 pathway in vitro.
  11. Anti-proliferative potential of curcumin in androgen-dependent prostate cancer cells occurs through modulation of the Wingless signaling pathway.
  12. Curcumin interrupts the interaction between the androgen receptor and Wnt/β-catenin signaling pathway in LNCaP prostate cancer cells.
  13. Curcumin-induced apoptosis in PC3 prostate carcinoma cells is caspase-independent and involves cellular ceramide accumulation and damage to mitochondria.
  14. Possible benefits of curcumin regimen in combination with taxane chemotherapy for hormone-refractory prostate cancer treatment.
  15. Chemopreventive potential of curcumin in prostate cancer.
  16. Multifunctional role of VIP in prostate cancer progression in a xenograft model: suppression by curcumin and COX-2 inhibitor NS-398.
  17. An evaluation of the anti-neoplastic activity of curcumin in prostate cancer cell lines.
  18. Prostate cancer and curcumin: add spice to your life.
  19. Curcumin blocks the activation of androgen and interlukin-6 on prostate-specific antigen expression in human prostatic carcinoma cells.
  20. Androgen responsive and refractory prostate cancer cells exhibit distinct curcumin regulated transcriptome.
  21. Murine prostate cancer inhibition by dietary phytochemicals–curcumin and phenyethylisothiocyanate.
  22. Curcumin inhibits the expression of vascular endothelial growth factor and androgen-independent prostate cancer cell line PC-3 in vitro].
  23. Curcumin sensitizes TRAIL-resistant xenografts: molecular mechanisms of apoptosis, metastasis and angiogenesis.
  24. MORE

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Turmeric vs. Cancer (Skin):

  1. Curcumin Intake Affects miRNA Signature in Murine Melanoma with mmu-miR-205-5p Most Significantly Altered.
  2. Chemo-resistant melanoma sensitized by tamoxifen to low dose curcumin treatment through induction of apoptosis and autophagy.
  3. Modulation of antioxidant defense by Alpinia galanga and Curcuma aromatica extracts correlates with their inhibition of UVA-induced melanogenesis.
  4. Xanthorrhizol inhibits 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation and two-stage mouse skin carcinogenesis by blocking the expression of ornithine decarboxylase, cyclooxygenase-2 and inducible nitric oxide synthase through mitogen-activated protein kinases and/or the nuclear factor-kappa B.
  5. Comparative potencies of nutraceuticals in chemically induced skin tumor prevention.
  6. Curcumin exhibits antimetastatic properties by modulating integrin receptors, collagenase activity, and expression of Nm23 and E-cadherin.
  7. Comparative potencies of nutraceuticals in chemically induced skin tumor prevention.
  8. Inhibition of carcinogen induced c-Ha-ras and c-fos proto-oncogenes expression by dietary curcumin.
  9. Suppression of mouse skin tumor promotion and induction of apoptosis in HL-60 cells by Alpinia oxyphylla Miquel (Zingiberaceae).
  10. Inhibitory effect of dietary curcumin on skin carcinogenesis in mice.
  11. Effect of dietary curcumin and ascorbyl palmitate on azoxymethanol-induced colonic epithelial cell proliferation and focal areas of dysplasia.
  12. Turmeric and curcumin as topical agents in cancer therapy.
  13. Anti-apoptotic effects of curcumin on photosensitized human epidermal carcinoma A431 cells.
  14. Curcumin inhibits UV irradiation-induced oxidative stress and apoptotic biochemical changes in human epidermoid carcinoma A431 cells.
  15. Curcumin Intake Affects miRNA Signature in Murine Melanoma with mmu-miR-205-5p Most Significantly Altered.
  16. Visible light is a better co-inducer of apoptosis for curcumin-treated human melanoma cells than UVA.
  17. Curcumin inhibits UV radiation-induced skin cancer in SKH-1 mice.
  18. Bcl-2 family proteins and cytoskeleton changes involved in DM-1 cytotoxic effect on melanoma cells.
  19. Topical curcumin-based cream is equivalent to dietary curcumin in a skin cancer model.
  20. Curcumin Protects against UVB-Induced Skin Cancers in SKH-1 Hairless Mouse: Analysis of Early Molecular Markers in Carcinogenesis.
  21. Curcumin inhibits melanogenesis in human melanocytes.
  22. Curcumin inhibits skin squamous cell carcinoma tumor growth in vivo.
  23. Targeting events in melanoma carcinogenesis for the prevention of melanoma.
  24. Chemoprevention of nonmelanoma skin cancer.
  25. Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations.
  26. Curcumin induces apoptosis in human melanoma cells through a Fas receptor/caspase-8 pathway independent of p53.

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Turmeric vs. Cancer (Testicular):

  1. Effects of curcumin on bleomycin‑induced oxidative stress in malignant testicular germ cell tumors.
  2. Synergistic anticancer activity of curcumin and bleomycin: an in vitro study using human malignant testicular germ cells.
  3. Curcumin inhibits AP-2γ-induced apoptosis in the human malignant testicular germ cells in vitro.
  4. Effects of curcumin on bleomycin‑induced oxidative stress in malignant testicular germ cell tumors.
  5. Curcumin derivatives inhibit testicular 17beta-hydroxysteroid dehydrogenase 3.

Turmeric vs. Cancer (Thyroid):

  1. Curcumin inhibits invasion and metastasis in K1 papillary thyroid cancer cells.
  2. Curcumin inhibits the metastasis of K1 papillary thyroid cancer cells via modulating E-cadherin and matrix metalloproteinase-9 expression.
  3. NTP Toxicology and Carcinogenesis Studies of Turmeric Oleoresin (CAS No. 8024-37-1) (Major Component 79%-85% Curcumin, CAS No. 458-37-7) in F344/N Rats and B6C3F1 Mice (Feed Studies).

Turmeric vs. Cholesterol:

  1. Curcuma oil ameliorates hyperlipidaemia and associated deleterious effects in golden Syrian hamsters.
  2. Curcumin induces changes in expression of genes involved in cholesterol homeostasis.
  3. Curcumin attenuates diet-induced hepatic steatosis by activating AMP-activated protein kinase.
  4. Molecular mechanism of curcumin on the suppression of cholesterol accumulation in macrophage foam cells and atherosclerosis.
  5. Effects and mechanism of turmeric vasorelaxation of the thoracic aorta in hypercholesterolemic rats.
  6. Attenuation of fatty liver and prevention of hypercholesterolemia by extract of Curcuma longa through regulating the expression of CYP7A1, LDL-receptor, HO-1, and HMG-CoA reductase.
  7. Potential mechanisms of hypocholesterolaemic effect of Thai spices/dietary extracts.
  8. Hypocholesterolemic effects of curcumin via up-regulation of cholesterol 7a-hydroxylase in rats fed a high fat diet.
  9. Potential mechanisms of hypocholesterolaemic effect of Thai spices/dietary extracts.
  10. Effect of Curcuma longa freeze dried rhizome powder with milk in STZ induced diabetic rats.
  11. Effect of cinnamon and turmeric on urinary oxalate excretion, plasma lipids, and plasma glucose in healthy subjects.
  12. Curcumin attenuates diet-induced hypercholesterolemia in rats.
  13. Effects of curcumin on cyclosporine-induced cholestasis and hypercholesterolemia and on cyclosporine metabolism in the rat.
  14. Oral administration of a turmeric extract inhibits LDL oxidation and has hypocholesterolemic effects in rabbits with experimental atherosclerosis.
  15. The influence of turmeric and curcumin on cholesterol concentration of eggs and tissues.

Turmeric vs. Cystic Fibrosis:

  1. Regulation of expression, function, and inflammatory responses of innate immune receptor Toll-like receptor-2 (TLR2) during inflammatory responses against infection].
  2. Curcumin cross-links cystic fibrosis transmembrane conductance regulator (CFTR) polypeptides and potentiates CFTR channel activity by distinct mechanisms.
  3. The potential role of natural agents in treatment of airway inflammation.
  4. Potential usefulness of curcumin in cystic fibrosis.
  5. Curcumin opens cystic fibrosis transmembrane conductance regulator channels by a novel mechanism that requires neither ATP binding nor dimerization of the nucleotide-binding domains.
  6. Curcumin enhances cystic fibrosis transmembrane regulator expression by down-regulating calreticulin.
  7. Rescue of DeltaF508-CFTR (cystic fibrosis transmembrane conductance regulator) by curcumin: involvement of the keratin 18 network.
  8. Curcumin stimulates cystic fibrosis transmembrane conductance regulator Cl- channel activity.
  9. Some like it hot: curcumin and CFTR.
  10. The spice of life for cystic fibrosis.
  11. Curcumin does not stimulate cAMP-mediated chloride transport in cystic fibrosis airway epithelial cells.
  12. Curcumin and cystic fibrosis.
  13. Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects.

Turmeric vs. Depression:

  1. Evaluation of antidepressant-like activity of novel water-soluble curcumin formulations and St. John’s wort in behavioral paradigms of despair.
  2. Effects of curcumin on chronic, unpredictable, mild, stress-induced depressive-like behaviour and structural plasticity in the lateral amygdala of rats.
  3. Chronic curcumin treatment normalizes depression-like behaviors in mice with mononeuropathy: involvement of supraspinal serotonergic system and GABA<sub>A</sub> receptor.
  4. Antidepressant-like effects of curcumin in chronic mild stress of rats: involvement of its anti-inflammatory action.
  5. Efficacy and Safety of Curcumin in Major Depressive Disorder: A Randomized Controlled Trial.
  6. NMDA GluN2B receptors involved in the antidepressant effects of curcumin in the forced swim test.
  7. Evaluation of antidepressant-like activity of novel water-soluble curcumin formulations and St. John’s wort in behavioral paradigms of despair.
  8. Curcumin inhibits glutamate release in nerve terminals from rat prefrontal cortex: possible relevance to its antidepressant mechanism.
  9. Gastroprotective and antidepressant effects of a new zinc(II)-curcumin complex in rodent models of gastric ulcer and depression induced by stresses.
  10. Antidepressant-like effects of curcumin on serotonergic receptor-coupled AC-cAMP pathway in chronic unpredictable mild stress of rats.
  11. Anti-depressant like effect of curcumin and its combination with piperine in unpredictable chronic stress-induced behavioral, biochemical and neurochemical changes.
  12. Antidepressant activity of curcumin: involvement of serotonin and dopamine system.
  13. Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB.
  14. Ethanolic extracts from Curcuma longa attenuates behavioral, immune, and neuroendocrine alterations in a rat chronic mild stress model.
  15. Antidepressant effects of curcumin in the forced swim test and olfactory bulbectomy models of depression in rats.
  16. Effects of Guanyu capsule on the behavior and cerebral cortex monoamine neurotransmitters in depressive model of olfactory bulb damage rats].
  17. Antidepressant activity of aqueous extracts of Curcuma longa in mice.
  18. Inflamed moods: A review of the interactions between inflammation and mood disorders.
  19. Neuroprotective and antioxidant effects of curcumin in a ketamine-induced model of mania in rats.
  20. Is there a role for curcumin in the treatment of bipolar disorder?

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Turmeric vs. Diabetes:

  1. A poly-herbal formulation accelerates normal and impaired diabetic wound healing.
  2. Modulatory effects of garlic, ginger, turmeric and their mixture on hyperglycaemia, dyslipidaemia and oxidative stress in streptozotocin-nicotinamide diabetic rats.
  3. Effect of Curcuma longa freeze dried rhizome powder with milk in STZ induced diabetic rats.
  4. Antihyperglycemic, antihyperlipidemic and antioxidant effects of Dihar, a polyherbal ayurvedic formulation in streptozotocin induced diabetic rats.
  5. Amelioration of renal lesions associated with diabetes by dietary curcumin in streptozotocin diabetic rats.
  6. Turmerin, the antioxidant protein from turmeric (Curcuma longa) exhibits antihyperglycaemic effects.
  7. Curcumin supplementation could improve diabetes-induced endothelial dysfunction associated with decreased vascular superoxide production and PKC inhibition.
  8. Synergistic effect of curcumin and insulin on muscle cell glucose metabolism.
  9. Curcumin attenuates the effects of insulin on stimulating hepatic stellate cell activation by interrupting insulin signaling and attenuating oxidative stress.
  10. Antihyperglycaemic effect of ‘Ilogen-Excel’, an ayurvedic herbal formulation in streptozotocin-induced diabetes mellitus.
  11. Curcumin, the active principle of turmeric (Curcuma longa), ameliorates diabetic nephropathy in rats.
  12. Effect of curcumin on protein glycosylation, lipid peroxidation, and oxygen radical generation in human red blood cells exposed to high glucose levels.
  13. Therapeutic implications of curcumin in the prevention of diabetic retinopathy via modulation of anti-oxidant activity and genetic pathways.
  14. Curcumin and Diabetes: A Systematic Review.
  15. Efficacy of biodegradable curcumin nanoparticles in delaying cataract in diabetic rat model.
  16. Targeted delivery of curcumin for treating type 2 diabetes.
  17. Discovering Bisdemethoxycurcumin from Curcuma longa rhizome as a potent small molecule inhibitor of human pancreatic α-amylase, a target for type-2 diabetes.
  18. Curcumin ameliorates hepatic fibrosis in type 2 diabetes mellitus – insights into its mechanisms of action.
  19. Turmeric (Curcuma longa L.) volatile oil inhibits key enzymes linked to type 2 diabetes.
  20. Effect of Curcuma longa freeze dried rhizome powder with milk in STZ induced diabetic rats.
  21. Curcumin improves prostanoid ratio in diabetic mesenteric arteries associated with cyclooxygenase-2 and NF-κB suppression.
  22. Activation of muscarinic M-1 cholinoceptors by curcumin to increase glucose uptake into skeletal muscle isolated from Wistar rats.
  23. Curcumin prevents diabetes-associated abnormalities in the kidneys by inhibiting p300 and nuclear factor-kappaB.
  24. A study on the hypoglycemic and hypolipidemic effects of an ayurvedic drug Rajanyamalakadi in diabetic patients.
  25. Curcuminoids modulates oxidative damage and mitochondrial dysfunction in diabetic rat brain.
  26. Curcumin inhibits glucose production in isolated mice hepatocytes.
  27. Effect of curcumin on hyperglycemia-induced vascular endothelial growth factor expression in streptozotocin-induced diabetic rat retina.
  28. Changes in glycoprotein components in streptozotocin–nicotinamide induced type 2 diabetes: influence of tetrahydrocurcumin from Curcuma longa.
  29. Curcumin alleviates diabetic cardiomyopathy in experimental diabetic rats.
  30. MORE

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Turmeric vs. Free Radicals:

  1. An evaluation of antioxidant, anti-inflammatory, and antinociceptive activities of essential oil from Curcuma longa. L.
  2. Dietary supplementation of curcumin enhances antioxidant and phase II metabolizing enzymes in ddY male mice: possible role in protection against chemical carcinogenesis and toxicity.
  3. Antioxidative effects of turmeric, rosemary and capsicum extracts on membrane phospholipid peroxidation and liver lipid metabolism in mice.
  4. The antiradical activity of some plant raw materials and extracts obtained from these raw materials.
  5. Curcumin protects against the oxidative damage induced by the pesticide parathion in the hippocampus of the rat brain.
  6. Bisdemethoxycurcumin protects endothelial cells against t-BHP-induced cell damage by regulating the phosphorylation level of ERK1/2 and Akt.
  7. Curcumin I protects the dopaminergic cell line SH-SY5Y from 6-hydroxydopamine-induced neurotoxicity through attenuation of p53-mediated apoptosis.
  8. Anti-inflammatory and anti-oxidant properties of Curcuma longa (turmeric) versus Zingiber officinale (ginger) rhizomes in rat adjuvant-induced arthritis.
  9. Antiproliferative, protective and antioxidant effects of artichoke, dandelion, turmeric and rosemary extracts and their formulation.
  10. Curcumin dramatically enhances retinoic acid-induced superoxide generating activity via accumulation of p47-phox and p67-phox proteins in U937 cells.
  11. Comment on Curcumin attenuates acrylamide-induced cytotoxicity and genotoxicity in HepG2 cells by ROS scavenging.
  12. The role of Curcuma longa against doxorubicin (adriamycin)-induced toxicity in rats.
  13. Antioxidative effects of curcumin and its analogues against the free-radical-induced peroxidation of linoleic acid in micelles.
  14. Possible nitric oxide modulation in protective effect of (Curcuma longa, Zingiberaceae) against sleep deprivation-induced behavioral alterations and oxidative damage in mice.
  15. Antioxidant and radical scavenging properties of curcumin.
  16. Antioxidant and iron-binding properties of curcumin, capsaicin, and S-allylcysteine reduce oxidative stress in rat brain homogenate.
  17. Effect of curcumin on chromium-induced oxidative damage in male reproductive system.
  18. Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism.
  19. Total phenol, antioxidant and free radical scavenging activities of some medicinal plants.
  20. The influence of curcumin and manganese complex of curcumin on cadmium-induced oxidative damage and trace elements status in tissues of mice.
  21. Curcumin blocks HIV protease inhibitor ritonavir-induced vascular dysfunction in porcine coronary arteries.
  22. Curcumin prevents methylglyoxal-induced oxidative stress and apoptosis in mouse embryonic stem cells and blastocysts.
  23. Antioxidant availability of turmeric in relation to its medicinal and culinary uses.
  24. A water extract of Curcuma longa L. (Zingiberaceae) rescues PC12 cell death caused by pyrogallol or hypoxia/reoxygenation and attenuates hydrogen peroxide induced injury in PC12 cells.
  25. Cytoprotective and cytotoxic effects of curcumin: dual action on H2O2-induced oxidative cell damage in NG108-15 cells.
  26. Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits.
  27. Diminution of singlet oxygen-induced DNA damage by curcumin and related antioxidants.
  28. Curcumin and (-)-epigallocatechin-3-gallate attenuate acrylamide-induced proliferation in HepG2 cells.

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Turmeric vs. Gastrointestinal Disorders:

  1. Therapeutic potential of curcumin in gastrointestinal diseases.
  2. Curcumin and its emerging role in the treatment and prevention of gastrointestinal diseases.
  3. Curcumin attenuates renal ischemia and reperfusion injury-induced restrictive respiratory insufficiency.
  4. Mechanisms of the protective effects of curcumin against indomethacin-induced gastric ulcer in rats.
  5. Turmeric (curcumin) remedies gastroprotective action.
  6. Gastroprotective and antidepressant effects of a new zinc(II)-curcumin complex in rodent models of gastric ulcer and depression induced by stresses.
  7. Investigation of the anti-inflammatory effect of Curcuma longa in Helicobacter pylori-infected patients.
  8. Comparative antiulcer effect of bisdemethoxycurcumin and curcumin in a gastric ulcer model system.
  9. Curcuma longa extract protects against gastric ulcers by blocking H2 histamine receptors.
  10. Phase II clinical trial on effect of the long turmeric (Curcuma longa Linn) on healing of peptic ulcer.
  11. The effects of a traditional drug, turmeric (Curcuma longa), and placebo on the healing of duodenal ulcer.
  12. Curcuma longa Linn. in the treatment of gastric ulcer comparison to liquid antacid: a controlled clinical trial.
  13. Thai herbal formulas used for wound treatment: a study of their antibacterial potency, anti-inflammatory, antioxidant, and cytotoxicity effects.
  14. Curcumin and its emerging role in the treatment and prevention of gastrointestinal diseases.
  15. Protective effects of curcumin supplementation on intestinal ischemia reperfusion injury.

Turmeric vs. Gonorrhea:

  1. The possible roles of vitamin D and curcumin in treating gonorrhea.
  2. The anti-inflammatory compound curcumin inhibits Neisseria gonorrhoeae-induced NF-kappaB signaling, release of pro-inflammatory cytokines/chemokines and attenuates adhesion in late infection.

Turmeric vs. Heart Disease:

  1. The protective role of curcumin in cardiovascular diseases.
  2. Antiatherosclerotic effects of dietary supplementations of garlic and turmeric: Restoration of endothelial function in rats.
  3. Cardioprotective effects of curcumin.
  4. Currying the heart: curcumin and cardioprotection.
  5. Currying favor for the heart.
  6. Curcumin promotes cardiac repair and ameliorates cardiac dysfunction following myocardial infarction.
  7. Curcumin reduces the cardiac ischemia-reperfusion injury: involvement of the toll-like receptor 2 in cardiomyocytes.
  8. Curcumin-Mediated Cardiac Defects in Mouse is Associated with a Reduced Histone H3 Acetylation and Reduced Expression of Cardiac Transcription Factors.
  9. Curcumin attenuation of lipopolysaccharide induced cardiac hypertrophy in rodents.
  10. SIRT1 activation by curcumin pretreatment attenuates mitochondrial oxidative damage induced by myocardial ischemia reperfusion injury.
  11. Application of curcumin to heart failure therapy by targeting transcriptional pathway in cardiomyocytes.
  12. Plant polyphenols in prevention of heart disease.
  13. Curcumin promotes cardiac repair and ameliorates cardiac dysfunction following myocardial infarction.
  14. Inhibition of histone acetylation by curcumin reduces alcohol-induced expression of heartdevelopment-related transcription factors in cardiac progenitor cells.
  15. Effects of curcuminoids on frequency of acute myocardial infarction after coronary artery bypass grafting.
  16. Effect of endurance exercise training and curcumin intake on central arterial hemodynamics in postmenopausal women: pilot study.
  17. A novel drug delivery system of oral curcumin markedly improves efficacy of treatment for heartfailure after myocardial infarction in rats.
  18. Curcumin ameliorates cardiac inflammation in rats with autoimmune myocarditis.
  19. Exercise training and antioxidants: effects on rat heart tissue exposed to lead acetate.
  20. Reversal of cardiac iron loading and dysfunction in thalassemic mice by curcuminoids.
  21. Effects of curcumin on sarcoplasmic reticulum Ca2+-ATPase in rabbits with heart failure].
  22. Novel heart failure therapy targeting transcriptional pathway in cardiomyocytes by a natural compound, curcumin.
  23. Protective effect of curcumin on experimentally induced inflammation, hepatotoxicity and cardiotoxicity in rats: evidence of its antioxidant property.
  24. Curcumin, resveratrol and flavonoids as anti-inflammatory, cyto- and DNA-protective dietary compounds.
  25. Curcumin prevents and reverses murine cardiac hypertrophy.
  26. Curcumin protects cardiac cells against ischemia-reperfusion injury: effects on oxidative stress, NF-kappaB, and JNK pathways.
  27. The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heartfailure in rats.
  28. Inhibition of NFkappaB activation with curcumin attenuates plasma inflammatory cytokines surge and cardiomyocytic apoptosis following cardiac ischemia/reperfusion.

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Turmeric vs. HIV / AIDS (weak):

  1. Inhibition of human immunodeficiency virus type-1 integrase by curcumin.
  2. Curcumin and curcumin derivatives inhibit Tat-mediated transactivation of type 1 human immunodeficiency virus long terminal repeat.
  3. Immunomodulatory effects of curcumin in allergy.
  4. Treatment of HIV-associated diarrhea with curcumin.
  5. Curcumin blocks HIV protease inhibitor ritonavir-induced vascular dysfunction in porcine coronary arteries.
  6. Inhibition of the HIV-1 and HIV-2 proteases by curcumin and curcumin boron complexes.
  7. Clinical Inquiry. Does turmeric relieve inflammatory conditions?
  8. Curcumin trial finds no activity.

Turmeric vs. Hypertension:

  1. Role of curcumin in idiopathic pulmonary arterial hypertension treatment: a new therapeutic possibility.
  2. Curcumin induces Nrf2 nuclear translocation and prevents glomerular hypertension, hyperfiltration, oxidant stress, and the decrease in antioxidant enzymes in 5/6 nephrectomized rats.
  3. Tetrahydrocurcumin alleviates hypertension, aortic stiffening and oxidative stress in rats with nitric oxide deficiency.
  4. Spice up the hypertension diet – curcumin and piperine prevent remodeling of aorta in experimental L-NAME induced hypertension.
  5. Oral supplementation of turmeric decreases proteinuria, hematuria, and systolic blood pressure in patients suffering from relapsing or refractory lupus nephritis: a randomized and placebo-controlled study.
  6. Antioxidant and vascular protective effects of curcumin and tetrahydrocurcumin in rats with L-NAME-induced hypertension.
  7. Effect of curcumin on pulmonary hypertension and wall collagen of pulmonary arterioles of chronic hypoxic hypercapnic rats].

Turmeric vs. Inflammation:

  1. Pulmonary administration of a water-soluble curcumin complex reduces severity of acute lung injury.
  2. Curcumin: an anti-inflammatory molecule from a curry spice on the path to cancer treatment.
  3. Anti-inflammatory effects of several plant extracts on porcine alveolar macrophages in vitro.
  4. Curcumin in inflammatory diseases.
  5. Modulation of steroid activity in chronic inflammation: a novel anti-inflammatory role for curcumin.
  6. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research.
  7. Curcumin inhibits pro-inflammatory mediators and metalloproteinase-3 production by chondrocytes.
  8. Modulation of inflammatory mediators by ibuprofen and curcumin treatment during chronic inflammation in rat.
  9. MORE

Turmeric vs. Jaundice:

  1. Effects of glutamine and curcumin on bacterial translocation in jaundiced rats.

Turmeric vs. Kidney Damage:

  1. Renoprotective effect of the antioxidant curcumin: Recent findings.
  2. The use of an anti-inflammatory supplement in patients with chronic kidney disease.
  3. Curcumin maintains cardiac and mitochondrial function in chronic kidney disease.
  4. Analysis of the gene expression profile of curcumin-treated kidney on endotoxin-induced renal inflammation.
  5. Nutritional compounds influence tissue factor expression and inflammation of chronic kidney disease patients in vitro.
  6. Curcumin prevents cardiac remodeling secondary to chronic renal failure through deactivation of hypertrophic signaling in rats.
  7. The role of Curcuma longa against doxorubicin (adriamycin)-induced toxicity in rats.
  8. Curcumin prevents diabetes-associated abnormalities in the kidneys by inhibiting p300 and nuclear factor-kappaB.
  9. Tetrahydrocurcumin: effect on chloroquine-mediated oxidative damage in rat kidney.
  10. Curcumin blocks multiple sites of the TGF-beta signaling cascade in renal cells.
  11. Effects of turmeric on uremic pruritus in end stage renal disease patients: a double-blind randomized clinical trial.
  12. Acute effects of diesel exhaust particles and cisplatin on oxidative stress in cultured human kidney (HEK 293) cells, and the influence of curcumin thereon.
  13. Dietary curcumin does not protect kidney in glycerol-induced acute renal failure.
  14. Curcumin provides incomplete protection of the kidney in ischemia reperfusion injury.
  15. Attenuation of high-glucose-induced inflammatory response by a novel curcumin derivative B06 contributes to its protection from diabetic pathogenic changes in rat kidney and heart.
  16. Curcumin attenuates lipopolysaccharide-induced renal inflammation.
  17. Influence of tetrahydrocurcumin on hepatic and renal functional markers and protein levels in experimental type 2 diabetic rats.
  18. Tetrahydrocurcumin: effect on chloroquine-mediated oxidative damage in rat kidney.
  19. Curcumin and especially tetrahydrocurcumin ameliorate oxidative stress-induced renal injury in mice.
  20. Effect of turmeric, turmerin and curcumin on H2O2-induced renal epithelial (LLC-PK1) cell injury.
  21. Curcumin alleviates oxidative stress, inflammation, and renal fibrosis in remnant kidney through the Nrf2-keap1 pathway.

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Turmeric vs. Liver Disorders:

  1. Protective effect of turmeric (Curcuma longa L.) extract on carbon tetrachloride-induced liver damage in rats.
  2. An ethanolic-aqueous extract of Curcuma longa decreases the susceptibility of liver microsomes and mitochondria to lipid peroxidation in atherosclerotic rabbits.
  3. Curcumin ameliorates mitochondrial dysfunction associated with inhibition of gluconeogenesis in free fatty acid-mediated hepatic lipoapoptosis.
  4. Curcumin reduces the toxic effects of iron loading in rat liver epithelial cells.
  5. Oral administration of a turmeric extract inhibits erythrocyte and liver microsome membrane oxidation in rabbits fed with an atherogenic diet.
  6. Curcumin Prevents Bile Canalicular Alterations in the Liver of Hamsters Infected with Opisthorchis viverrini.
  7. Curcumin and liver disease.
  8. Phyto-power dietary supplement potently inhibits dimethylnitrosamine-induced liver fibrosis in rats.
  9. Inhibition by curcumin of multiple sites of the transforming growth factor-beta1 signalling pathway ameliorates the progression of liver fibrosis induced by carbon tetrachloride in rats.
  10. Curcumin inhibits iron overload-induced hepatocytic apoptosis and nuclear factor-κB activity].
  11. Protective effects of curcumin against hepatic fibrosis induced by carbon tetrachloride: modulation of high-mobility group box 1, Toll-like receptor 4 and 2 expression.
  12. Curcumin ameliorates hepatic fibrosis in type 2 diabetes mellitus – insights into its mechanisms of action.
  13. Negative effects of curcumin on liver injury induced by alcohol.
  14. Curcumin protects against thioacetamide-induced hepatic fibrosis by attenuating the inflammatory response and inducing apoptosis of damaged hepatocytes.
  15. Protective effects of kaerophyllin against liver fibrogenesis in rats.
  16. Protective effects of curcumin, α-lipoic acid, and N-acetylcysteine against carbon tetrachloride-induced liver fibrosis in rats.
  17. Reduction of periductal fibrosis in liver fluke-infected hamsters after long-term curcumin treatment.
  18. Curcumin improves sclerosing cholangitis in Mdr2-/- mice by inhibition of cholangiocyte inflammatory response and portal myofibroblast proliferation.
  19. Effect of curcumin on growth and function of fibroblast in human hyperplastic scar].
  20. Curcumin and saikosaponin a inhibit chemical-induced liver inflammation and fibrosis in rats.
  21. Curcumin protects against hepatic and renal injuries mediated by inducible nitric oxide synthase during selenium-induced toxicity in Wistar rats.
  22. Pharmacological actions of curcumin in liver diseases or damage.
  23. Curcumin adds spice to the debate: lipid metabolism in liver disease.
  24. Curcumin prevents liver fibrosis by inducing apoptosis and suppressing activation of hepatic stellate cells.
  25. Curcumin prevents and reverses cirrhosis induced by bile duct obstruction or CCl4 in rats: role of TGF-beta modulation and oxidative stress.
  26. The study of therapeutic effects of curcumin on hepatic fibrosis and variation of correlated cytokine].
  27. Curcumin: potential for hepatic fibrosis therapy?
  28. Therapeutic effects of curcumin treatment on hepatic fibrosis].
  29. Prevention of liver cirrhosis in rats by curcumin.
  30. Therapeutic potential of curcumin in non-alcoholic steatohepatitis.

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Turmeric vs. Lung Disease:

  1. Dietary curcumin increases antioxidant defenses in lung, ameliorates radiation-induced pulmonary fibrosis, and improves survival in mice.
  2. Experimental study on effect of curcumin on inhibiting injury of free radical in pulmonary fibrosis rats].
  3. Curcumin modulates the inflammatory response and inhibits subsequent fibrosis in a mouse model of viral-induced acute respiratory distress syndrome.
  4. Modulatory effects of curcumin and green tea extract against experimentally induced pulmonary fibrosis: a comparison with N-acetyl cysteine.
  5. Curcumin inhibits fibrosis-related effects in IPF fibroblasts and in mice following bleomycin-induced lung injury.
  6. Antifibrotic effects of curcumin are associated with overexpression of cathepsins K and L in bleomycin treated mice and human fibroblasts.
  7. Curcumin attenuates radiation-induced inflammation and fibrosis in rat lungs.
  8. Effects of curcumin on apoptosis of pulmonary fibroblasts from rats].
  9. Effects of curcumin on TNF-alpha and TGF-beta1 in serum and lung tissue of SiO2-induced fibrosis in mice].
  10. Preventive effects of curcumin on different aspiration material-induced lung injury in rats.
  11. Protection from acute and chronic lung diseases by curcumin.
  12. Pulmonary protective effects of curcumin against paraquat toxicity.
  13. Curcumin attenuates staphylococcus aureus-induced acute lung injury.
  14. The effect of curcumin on lung injuries in a rat model induced by aspirating gastrointestinal decontamination agents.
  15. The effect of curcumin on sepsis-induced acute lung injury in a rat model through the inhibition of the TGF-β1/SMAD3 pathway.
  16. Pharmacological and dietary antioxidant therapies for chronic obstructive pulmonary disease.
  17. Protective effect of curcumin on pulmonary and cardiovascular effects induced by repeated exposure to diesel exhaust particles in mice.
  18. Curcumin for the prevention of acute lung injury in sepsis: is it more than the flavor of the month?
  19. Pulmonary administration of a water-soluble curcumin complex reduces severity of acute lung injury.
  20. Curcumin augments lung maturation, preventing neonatal lung injury by inhibiting TGF-β signaling.
  21. The preventative role of curcumin on the lung inflammatory response induced by cardiopulmonary bypass in rats.
  22. Curcumin alone and in combination with augmentin protects against pulmonary inflammation and acute lung injury generated during Klebsiella pneumoniae B5055-induced lung infection in BALB/c mice.
  23. Protective effect of curcumin on endotoxin-induced acute lung injury in rats.
  24. Comparative effects of curcumin and its synthetic analogue on tissue lipid peroxidation and antioxidant status during nicotine-induced toxicity.
  25. Modulatory effects of curcumin on lipid peroxidation and antioxidant status during nicotine-induced toxicity.
  26. Curcumin-induced apoptosis in scleroderma lung fibroblasts: role of protein kinase cepsilon.
  27. Protective effect of curcumin on circulatory lipid peroxidation and antioxidant status during nicotine-induced toxicity.
  28. Protective effects of curcumin against amiodarone-induced pulmonary fibrosis in rats.

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Turmeric vs. Lupus:

  1. Oral supplementation of turmeric decreases proteinuria, hematuria, and systolic blood pressure in patients suffering from relapsing or refractory lupus nephritis: a randomized and placebo-controlled study.
  2. Curcumin attenuates lupus nephritis upon interaction with regulatory T cells in New Zealand Black/White mice.
  3. Curcumin aggravates CNS pathology in experimental systemic lupus erythematosus.

Turmeric vs. Mustard Gas:

  1. A randomized controlled trial on the anti-inflammatory effects of curcumin in patients with chronic sulphur mustard-induced cutaneous complications.
  2. Improvement of sulphur mustard-induced chronic pruritus, quality of life and antioxidant status by curcumin: results of a randomised, double-blind, placebo-controlled trial.

Turmeric vs. Obesity:

  1. Curcumin decreases oxidative stress in mitochondria isolated from liver and kidneys of high-fat diet-induced obese mice.
  2. Anti-obesity effect of a standardised ethanol extract from Curcuma longa L. fermented with Aspergillus oryzae in ob/ob mice and primary mouse adipocytes.
  3. Effect of Curcuma kwangsiensis polysaccharides on blood lipid profiles and oxidative stress in high-fat rats.
  4. Effects of ingested turmeric oleoresin on glucose and lipid metabolisms in obese diabetic mice: a DNA microarray study.
  5. Protective Role of a Novel Curcuminoid on Alcohol and PUFA-Induced Hyperlipidemia.
  6. Curcumin molecular targets in obesity and obesity-related cancers.
  7. New mechanisms and the anti-inflammatory role of curcumin in obesity and obesity-related metabolic diseases.
  8. Effect of curcumin on protein glycosylation, lipid peroxidation, and oxygen radical generation in human red blood cells exposed to high glucose levels.
  9. Curcuminoids: Spicing up sympathovagal tone.
  10. Novel insights of dietary polyphenols and obesity.
  11. Curcuma longa extract associated with white pepper lessens high fat diet-induced inflammation in subcutaneous adipose tissue.
  12. Dietary polyphenols suppress elevated levels of proinflammatory mediators and aromatase in the mammary gland of obese mice.
  13. Caloric restriction favorably impacts metabolic and immune/inflammatory profiles in obese mice but curcumin/piperine consumption adds no further benefit.
  14. Curcumin and obesity.
  15. Positive effect of curcumin on inflammation and mitochondrial dysfunction in obese mice with liver steatosis.
  16. Amelioration of obesity, glucose intolerance, and oxidative stress in high-fat diet and low-dose streptozotocin-induced diabetic rats by combination consisting of “curcumin with piperine and quercetin”.
  17. Curcumin molecular targets in obesity and obesity-related cancers.
  18. Curcumin prevents high fat diet induced insulin resistance and obesity via attenuating lipogenesis in liver and inflammatory pathway in adipocytes.
  19. Effect of citrus polyphenol- and curcumin-supplemented diet on inflammatory state in obese cats.
  20. Curcumin suppresses intestinal polyps in APC Min mice fed a high fat diet.
  21. Curcumin and obesity: evidence and mechanisms.
  22. Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals.
  23. Curcumin inhibits adipogenesis in 3T3-L1 adipocytes and angiogenesis and obesity in C57/BL mice.
  24. Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity.

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Turmeric vs. Nerve Damage:

  1. An overview of curcumin in neurological disorders.
  2. An Experimental Comparison of the Effects of Propolis, Curcumin, and Methylprednisolone on Crush Injuries of the Sciatic Nerve.
  3. Curcumin protects the dorsal root ganglion and sciatic nerve after crush in rat.
  4. Curcumin derivatives promote Schwann cell differentiation and improve neuropathy in R98C CMT1B mice.
  5. Effect of curcumin on diabetic peripheral neuropathic pain: Possible involvement of opioid system.
  6. Molecular understanding of curcumin in diabetic nephropathy.
  7. Oral supplementation of turmeric attenuates proteinuria, transforming growth factor-β and interleukin-8 levels in patients with overt type 2 diabetic nephropathy: a randomized, double-blind and placebo-controlled study.
  8. Curcumin ameliorates diabetic nephropathy by inhibiting the activation of the SphK1-S1P signaling pathway.
  9. Curcumin could prevent the development of chronic neuropathic pain in rats with peripheral nerve injury.
  10. Curcumin ameliorated diabetic neuropathy partially by inhibition of NADPH oxidase mediating oxidative stress in the spinal cord.
  11. Neuroprotective effect of geraniol and curcumin in an acrylamide model of neurotoxicity in Drosophila melanogaster: relevance to neuropathy.
  12. Safety and efficacy of an add-on therapy with curcumin phytosome and piperine and/or lipoic acid in subjects with a diagnosis of peripheral neuropathy treated with dexibuprofen.
  13. The effect of curcumin on oxaliplatin and cisplatin neurotoxicity in rats: some behavioral, biochemical, and histopathological studies.
  14. Protective effects of combined therapy of gliclazide with curcumin in experimental diabetic neuropathy in rats.
  15. Improvement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington’s disease.
  16. Protective effect of Curcumin, the active principle of turmeric (Curcuma longa) in haloperidol-induced orofacial dyskinesia and associated behavioural, biochemical and neurochemical changes in rat brain.
  17. The effect of chelidonium- and turmeric root extract on upper abdominal pain due to functional disorders of the biliary system. Results from a placebo-controlled double-blind study].
  18. Effect of oral curcumin on Déjérine-Sottas disease.
  19. Diagnosis, natural history, and management of Charcot-Marie-Tooth disease.
  20. Hereditary neuropathy: recent advance].
  21. Oral curcumin mitigates the clinical and neuropathologic phenotype of the Trembler-J mouse: a potential therapy for inherited neuropathy.
  22. Curcumin treatment abrogates endoplasmic reticulum retention and aggregation-induced apoptosis associated with neuropathy-causing myelin protein zero-truncating mutants.

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Turmeric vs. Parkinson’s Disease:

  1. Curcumin: a potential neuroprotective agent in Parkinson’s disease.
  2. Therapeutic potential of dietary polyphenols against brain ageing and neurodegenerative disorders.
  3. Curcumin protects against A53T alpha-synuclein-induced toxicity in a PC12 inducible cell model for Parkinsonism.
  4. Bioconjugates of curcumin display improved protection against glutathione depletion mediated oxidative stress in a dopaminergic neuronal cell line: Implications for Parkinson’s disease.
  5. Curcumin and its derivatives: their application in neuropharmacology and neuroscience in the 21st century.
  6. Curcumin ameliorates the neurodegenerative pathology in A53T α-synuclein cell model of Parkinson’s disease through the downregulation of mTOR/p70S6K signaling and the recovery of macroautophagy.
  7. Chronic dietary supplementation with turmeric protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-mediated neurotoxicity in vivo: implications for Parkinson’s disease.
  8. Curcumin treatment alleviates the effects of glutathione depletion in vitro and in vivo: therapeutic implications for Parkinson’s disease explained via in silico studies.

Turmeric vs. Rett Syndrome:

  1. Vascular dysfunction in a mouse model of Rett syndrome and effects of curcumin treatment.

Turmeric vs. Scabies:

  1. The use and efficacy of Azadirachta indica ADR (‘Neem’) and Curcuma longa (‘Turmeric’) in scabies. A pilot study.

Turmeric vs. Skin Aging:

  1. Skin regenerative potentials of curcumin.
  2. Curcumin induces heme oxygenase-1 in normal human skin fibroblasts through redox signaling: relevance for anti-aging intervention.
  3. Beneficial role of curcumin in skin diseases.
  4. Low concentrations of curcumin induce growth arrest and apoptosis in skin keratinocytes only in combination with UVA or visible light.
  5. Protective effects of curcumin against oxidative damage on skin cells in vitro: its implication for wound healing.
  6. Protective effect of curcuminoids on epidermal skin cells under free oxygen radical stress.
  7. Curcumin: a novel treatment for skin-related disorders.
  8. Combined effect of PLGA and curcumin on wound healing activity.
  9. Preparation of curcumin-loaded liposomes and evaluation of their skin permeation and pharmacodynamics.
  10. Bioactive compounds from natural resources against skin aging.
  11. Preparation of curcuminoid niosomes for enhancement of skin permeation.
  12. Curcumin targeted signaling pathways: basis for anti-photoaging and anti-carcinogenic therapy.
  13. Inhibitory effect of encapsulated curcumin on ultraviolet-induced photoaging in mice.
  14. Wound healing in adult skin: aiming for perfect regeneration.

Turmeric vs. Skin Burns & Wounds:

  1. A biodegradable hydrogel system containing curcumin encapsulated in micelles for cutaneous wound healing.
  2. The effects of topical treatment with curcumin on burn wound healing in rats.
  3. Signaling pathways targeted by curcumin in acute and chronic injury: burns and photo-damaged skin.
  4. Wound healing in adult skin: aiming for perfect regeneration.
  5. Acceleration of wound repair by curcumin in the excision wound of mice exposed to different doses of fractionated γ radiation.
  6. A systematic review of topical treatments to control the odor of malignant fungating wounds.
  7. Chitosan-alginate sponge: preparation and application in curcumin delivery for dermal wound healing in rat.
  8. A combination of curcumin and ginger extract improves abrasion wound healing in corticosteroid-impaired hairless rat skin.
  9. Curcumin reduces burn progression in rats.
  10. Curcumin improves wound healing by modulating collagen and decreasing reactive oxygen species.
  11. Curcumin treatment enhances the repair and regeneration of wounds in mice exposed to hemibody gamma-irradiation.
  12. Dermal wound healing processes with curcumin incorporated collagen films.
  13. Antimicrobial emulsion (coating) based on biopolymer containing neem (Melia azardichta) and turmeric (Curcuma longa) extract for wound covering.
  14. Curcumin: a novel therapeutic for burn pain and wound healing.

Turmeric vs. Tooth Decay:

  1. Role of curcumin in systemic and oral health: An overview.
  2. Comparative evaluation of turmeric and chlorhexidine gluconate mouthwash in prevention of plaque formation and gingivitis: a clinical and microbiological study.
  3. Histological evaluation of Curcuma longa-ghee formulation and hyaluronic acid on gingival healing in dog.
  4. Antibacterial activity of Curcuma longa L. against methicillin-resistant Staphylococcus aureus.
  5. Potent anti-inflammatory effects of systemically administered curcumin modulate periodontal disease in vivo.
  6. Effectiveness of sub gingival irrigation of an indigenous 1% curcumin solution on clinical and microbiological parameters in chronic periodontitis patients: A pilot randomized clinical trial.
  7. Efficacy of curcumin in the treatment of chronic gingivitis: a pilot study.
  8. Curcumin modulates the immune response associated with LPS-induced periodontal disease in rats.
  9. Anti-inflammatory activity of curcumin in macrophages stimulated by lipopolysaccharides from Porphyromonas gingivalis.

Curcumin Chemistry & Basic Solubility

  1. Microencapsulation by freeze-drying of potassium norbixinate and curcumin with maltodextrin: stability, solubility, and food application.
  2. Temperature-dependent spectroscopic evidences of curcumin in aqueous medium: a mechanistic study of its solubility and stability.
  3. Curcumin derivatives: molecular basis of their anti-cancer activity.
  4. Curcumin content of turmeric and curry powders.
  5. Role of Surfactant and pH in Dissolution of Curcumin.
  6. Phase behavior and oral bioavailability of amorphous Curcumin.
  7. Conundrum and therapeutic potential of curcumin in drug delivery.
  8. Improving the solubility and pharmacological efficacy of curcumin by heat treatment.
  9. Curcumin/turmeric solubilized in sodium hydroxide inhibits HNE protein modification–an in vitro study.
  10. Recent studies on the biofunctions and biotransformations of curcumin.
  11. In vitro and in vivo evaluation of curcumin loaded lauroyl sulphated chitosan for enhancing oral bioavailability.
  12. Plasma proteins interaction with curcumin nanoparticles: implications in cancer therapeutics.
  13. Improved bioavailability of poorly water-soluble drug curcumin in cellulose acetate solid dispersion.
  14. Binding of curcumin to milk proteins increases after static high pressure treatment of skim milk.
  15. Development and evaluation of a novel phytosome-loaded chitosan microsphere system for curcumin delivery.
  16. Curcumin loaded nano globules for solubility enhancement: preparation, characterization and ex vivo release study.
  17. Delivery of curcumin and medicinal effects of the copper(II)-curcumin complexes.
  18. Fast dissolving eutectic compositions of curcumin.
  19. Physiological barriers to the oral delivery of curcumin.
  20. Preparation and enhancement of oral bioavailability of curcumin using microemulsions vehicle.
  21. Influence of cosolvents, ionic strength and the method of sample preparation on the solubilization of curcumin by Pluronics and HP-gamma-cyclodextrin. Studies of curcumin and curcuminoids, XLIV.
  22. Preparation of curcumin solid dispersion and inclusion complex.
  23. Hydrocolloid-based nutraceutical delivery systems.
  24. Impact of curcumin supersaturation in antibacterial photodynamic therapy–effect of cyclodextrin type and amount: studies on curcumin and curcuminoides XLV.
  25. Enhancement of curcumin oral absorption and pharmacokinetics of curcuminoids and curcumin metabolites in mice.
  26. Extending the applicability of pressurized hot water extraction to compounds exhibiting limited water solubility by pH control: curcumin from the turmeric rhizome.
  27. Interaction of curcumin and bixin with β-cyclodextrin: complexation methods, stability, and applications in food.
  28. Bioavailability enhancement of curcumin by complexation with phosphatidyl choline.
  29. Modification of curcumin with polyethylene glycol enhances the delivery of curcumin in preadipocytes and its antiadipogenic property.

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Curcuminoid Detection & Extraction

  1. Separation and free radical-scavenging activity of major curcuminoids of Curcuma longa using HPTLC-DPPH method.
  2. Quick supramolecular solvent-based microextraction for quantification of low curcuminoid content in food.
  3. Optimization and validation of high-performance liquid chromatography method for individual curcuminoids in turmeric by heat-refluxed extraction.
  4. A Versatile Liquid Chromatographic Technique for Pharmacokinetic Estimation of Curcumin in Human Plasma.
  5. Preparation of monodisperse curcumin-imprinted polymer by precipitation polymerization and its application for the extraction of curcuminoids from Curcuma longa L.
  6. In-line cold column trapping of organic phase in dispersive liquid-liquid microextraction: enrichment and determination of curcumin in human serum.
  7. Extending the applicability of pressurized hot water extraction to compounds exhibiting limited water solubility by pH control: curcumin from the turmeric rhizome.
  8. Extending the applicability of pressurized hot water extraction to compounds exhibiting limited water solubility by pH control: curcumin from the turmeric rhizome.
  9. A validated method for the quantification of curcumin in plasma and brain tissue by fast narrow-bore high-performance liquid chromatography with fluorescence detection.
  10. Analysis of minor curcuminoids in Curcuma longa L. by high performance liquid chromatography-tandem mass spectrometry].
  11. Comparison of extraction methods for the analysis of natural dyes in historical textiles by high-performance liquid chromatography.
  12. Purification and characterization of a approximately 34 kDa antioxidant protein (beta-turmerin) from turmeric (Curcuma longa) waste grits.
  13. Design and optimization of ultrasound assisted extraction of curcumin as an effective alternative for conventional solid liquid extraction of natural products.
  14. A simple HPLC-fluorescence method for quantitation of curcuminoids and its application to turmeric products.
  15. A simple 2-directional high-performance thin-layer chromatographic method for the simultaneous determination of curcumin, metanil yellow, and sudan dyes in turmeric, chili, and curry powders.
  16. Rapid analysis of curcumin and curcumin metabolites in rat biomatrices using a novel ultraperformance liquid chromatography (UPLC) method.
  17. Extraction, processing, and storage effects on curcuminoids and oleoresin yields from Curcuma longa L. grown in Jamaica.
  18. Microwave assisted extraction of curcumin by sample-solvent dual heating mechanism using Taguchi L9 orthogonal design.
  19. Isolation and characterization of antioxidation enzymes from cells of zedoary (Curcuma zedoaria Roscoe) cultured in a 5-l bioreactor.
  20. Standardization and stability studies of neuroprotective lipid soluble fraction obtained from Curcuma longa.
  21. High-performance liquid chromatography analysis of curcumin in rat plasma: application to pharmacokinetics of polymeric micellar formulation of curcumin.
  22. Quantitative determination of eight components in rhizome (Jianghuang) and tuberous root (Yujin) of Curcuma longa using pressurized liquid extraction and gas chromatography-mass spectrometry.
  23. Microemulsion electrokinetic chromatography for separation and analysis of curcuminoids in turmeric samples.
  24. Detection and quantitation of curcumin in mouse lung cell cultures by matrix-assisted laser desorption ionization time of flight mass spectrometry.
  25. Quantitative determination of curcuminoids in Curcuma rhizomes and rapid differentiation of Curcuma domestica Val. and Curcuma xanthorrhiza Roxb. by capillary electrophoresis.
  26. Extraction of essential oil and pigments from Curcuma longa [L] by steam distillation and extraction with volatile solvents.
  27. Sensitive and rapid isocratic liquid chromatography method for the quantitation of curcumin in plasma.
  28. Comparison of yield, composition, and antioxidant activity of turmeric (Curcuma longa L.) extracts obtained using various techniques.
  29. Capillary electrophoresis with amperometric detection of curcumin in Chinese herbal medicine pretreated by solid-phase extraction.

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Solubility & Curcuminoid Drug Delivery:

  1. Increasing aqueous solubility of curcumin for improving bioavailability.
  2. Systemic delivery of curcumin: 21st century solutions for an ancient conundrum.
  3. Increasing the solubility of the nutraceutical curcumin by heat and inhibition of oxidative modification.
  4. Determination of acidity constants of curcumin in aqueous solution and apparent rate constant of its decomposition.
  5. Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer.
  6. Bubbling hookah smoke through heat-solubilized curcumin/turmeric and incorporation of the curry spice as an additive or filter in cigarettes to minimize tobacco smoke-related toxicants.
  7. Impact of curcumin supersaturation in antibacterial photodynamic therapy–effect of cyclodextrin type and amount: studies on curcumin and curcuminoides XLV.
  8. Development of curcumin nanocrystal: physical aspects.
  9. Excited-state dynamics of bis-dehydroxycurcumin carboxylic acid, a water-soluble derivative of the photosensitizer curcumin.
  10. Microbial Transformation of Curcumin to Its Derivatives with a Novel Pichia kudriavzevii ZJPH0802 Strain.
  11. Design and synthesis of dimethylaminomethyl-substituted curcumin derivatives/analogues: potent antitumor and antioxidant activity, improved stability and aqueous solubility compared with curcumin.
  12. Curcumin loaded NIPAAM/VP/PEG-A nanoparticles: physicochemical and chemopreventive properties.
  13. Design, optimization and quality evaluation of curcumin self-emulsifying drug delivery system (SEDDS).
  14. Gelucire44/14 as a novel absorption enhancer for drugs with different hydrophilicities: in vitro and in vivo improvement on transcorneal permeation.
  15. Interaction of curcumin and bixin with β-cyclodextrin: complexation methods, stability, and applications in food.
  16. Curcumin nanoparticles: preparation, characterization, and antimicrobial study.
  17. Controlled release of oral tetrahydrocurcumin from a novel self-emulsifying floating drug delivery system (SEFDDS).
  18. Identification of permeability-related hurdles in oral delivery of curcumin using the Caco-2 cell model.
  19. Preparation and characterization of intravenously injectable curcumin nanosuspension.
  20. Synthesis and characterization of a cytotoxic cationic polyvinylpyrrolidone-curcumin conjugate.
  21. Evaluation of curcumin acetates and amino acid conjugates as proteasome inhibitors.
  22. Self-microemulsifying drug delivery system improves curcumin dissolution and bioavailability.
  23. Development and evaluation of self-microemulsifying liquid and pellet formulations of curcumin, and absorption studies in rats (SMEDDS).
  24. Cyclodextrin-complexed curcumin exhibits anti-inflammatory and antiproliferative activities superior to those of curcumin through higher cellular uptake.
  25. Preparation of curcumin sub-micrometer dispersions by high-pressure homogenization.
  26. Formulation, characterization and evaluation of curcumin-loaded PLGA nanospheres for cancer therapy.
  27. Development of curcuminoids loaded poly(butyl) cyanoacrylate nanoparticles: Physicochemical characterization and stability study.
  28. Differential solubility of curcuminoids in serum and albumin solutions: implications for analytical and therapeutic applications.
  29. Studies on solubility enhancement of curcumin by Polyvinylpyrrolidione K30.
  30. Design, synthesis and characterization of some bioactive conjugates of curcumin with glycine, glutamic acid, valine and demethylenated piperic acid and study of their antimicrobial and antiproliferative properties.
  31. Solubility of core materials in aqueous polymeric solution effect on microencapsulation of curcumin.
  32. Characterization of curcumin-PVP solid dispersion obtained by spray drying.
  33. How curcumin works preferentially with water soluble antioxidants.

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Curcuminoid Drug Delivery Research

Curcuminoid Drug Delivery (Breast Cancer):

  1. Dendrimer-curcumin Conjugate: A Water Soluble and Effective Cytotoxic Agent against Breast Cancer Cell Lines.
  2. Curcumin loaded polymeric micelles inhibit breast tumor growth and spontaneous pulmonary metastasis.
  3. Preparation and characterization of albumin nanoparticles encapsulating curcumin intended for the treatment of breast cancer.

Curcuminoid Drug Delivery (Colon Cancer):

  1. Curcumin-containing chitosan nanoparticles as a potential mucoadhesive delivery system to the colon.
  2. In vitro evaluation of Moringa oleifera gum for colon-specific drug delivery.
  3. Eudragit® S100 coated calcium pectinate microspheres of curcumin for colon targeting.
  4. Synergistic anticancer activity of curcumin and catechin: an in vitro study using human cancer cell lines.
  5. A novel solubility-enhanced curcumin formulation showing stability and maintenance of anticancer activity.
  6. Curcumin-loaded biodegradable polymeric micelles for colon cancer therapy in vitro and in vivo.
  7. Colon targeted curcumin delivery using guar gum.
  8. Curcumin loaded pH-sensitive nanoparticles for the treatment of colon cancer.
  9. A novel plug-controlled colon-specific pulsatile capsule with tablet of curcumin-loaded SMEDDS.
  10. Novel micelle formulation of curcumin for enhancing antitumor activity and inhibiting colorectal cancer stem cells.
  11. Chemoprevention of azoxymethane-initiated colon cancer in rat by using a novel polymeric nanocarrier–curcumin.
  12. A novel folate-modified self-microemulsifying drug delivery system of curcumin for colon targeting.
  13. In vitro cytotoxicity and cellular uptake of curcumin-loaded Pluronic/Polycaprolactone micelles in colorectal adenocarcinoma cells.

Curcuminoid Drug Delivery (Exotic):

  1. Formulation and bacterial phototoxicity of curcumin loaded alginate foams for wound treatment applications: studies on curcumin and curcuminoides XLII.
  2. Preparation, characterization, pharmacokinetics, and tissue distribution of curcumin nanosuspension with TPGS as stabilizer.
  3. Studies on preparation and dissolution test in vitro of sustained-release dropping pills of curcumin.
  4. Drug targeting to the hair follicles: a cyclodextrin-based drug delivery.
  5. Curcumin-encapsulated MePEG/PCL diblock copolymeric micelles: a novel controlled delivery vehicle for cancer therapy.
  6. Heat-solubilized curry spice curcumin inhibits antibody-antigen interaction in in vitro studies: a possible therapy to alleviate autoimmune disorders.
  7. Formulation design and photochemical studies on nanocrystal solid dispersion of curcumin with improved oral bioavailability.
  8. Study on the antibiotic activity of microcapsule curcumin against foodborne pathogens.
  9. Novel formulation of solid lipid microparticles of curcumin for anti-angiogenic and anti-inflammatory activity for optimization of therapy of inflammatory bowel disease.
  10. Novel artemisinin and curcumin micellar formulations: drug solubility studies by NMR spectroscopy.

Curcuminoid Drug Delivery (Lung Cancer):

  1. Curcumin-cyclodextrin complexes potentiate gemcitabine effects in an orthotopic mouse model of lung cancer.
  2. A systemic administration of liposomal curcumin inhibits radiation pneumonitis and sensitizes lung carcinoma to radiation.
  3. Preparation and characterization of curcumin loaded gelatin microspheres for lung targeting].

Curcuminoid Drug Delivery (Malaria):

  1. Curcuminoids-loaded lipid nanoparticles: novel approach towards malaria treatment.

Curcuminoid Drug Delivery (Multi-Cancer):

  1. A novel solubility-enhanced curcumin formulation showing stability and maintenance of anticancer activity.
  2. Curcumin and its formulations: potential anti-cancer agents.
  3. Multitargeting by curcumin as revealed by molecular interaction studies.
  4. Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers.
  5. Encapsulation of curcumin in self-assembling peptide hydrogels as injectable drug delivery vehicles.
  6. Preparation and characterization of water-soluble albumin-bound curcumin nanoparticles with improved antitumor activity.
  7. Hollow microcapsules built by layer by layer assembly for the encapsulation and sustained release of curcumin.
  8. Synergistic Interaction of Paclitaxel and Curcumin with Cyclodextrin Polymer Complexation in Human Cancer Cells.
  9. A supermolecular curcumin for enhanced antiproliferative and proapoptotic activities: molecular characteristics, computer modeling and in vivo pharmacokinetics.
  10. Silica-coated flexible liposomes as a nanohybrid delivery system for enhanced oral bioavailability of curcumin.
  11. Novel dipeptide nanoparticles for effective curcumin delivery.
  12. Preparation and in vivo pharmacokinetics of curcumin-loaded PCL-PEG-PCL triblock copolymeric nanoparticles.
  13. Synthesis of novel biodegradable methoxy poly(ethylene glycol)-zein micelles for effective delivery of curcumin.
  14. Invertible micellar polymer assemblies for delivery of poorly water-soluble drugs.
  15. Curcumin encapsulation in submicrometer spray-dried chitosan/Tween 20 particles.
  16. Synthesis, release ability and bioactivity evaluation of chitin beads incorporated with curcumin for drug delivery applications.
  17. Alkyl cinnamates as regulator for the C1 domain of protein kinase C isoforms.
  18. Preparation and in vitro evaluation of a folate-linked liposomal curcumin formulation.
  19. Synthesis and evaluation of curcumin-related compounds for anticancer activity.
  20. Gold nanoparticles generated and stabilized by water soluble curcumin-polymer conjugate: blood compatibility evaluation and targeted drug delivery onto cancer cells.
  21. Coupling to a cancer cell-specific antibody potentiates tumoricidal properties of curcumin.
  22. Highly loaded, sustained-release microparticles of curcumin for chemoprevention.
  23. Advanced drug delivery systems of curcumin for cancer chemoprevention.
  24. Bioavailability enhancement of curcumin by complexation with phosphatidyl choline.
  25. A novel solubility-enhanced curcumin formulation showing stability and maintenance of anticancer activity.
  26. Indian gold treating cancer in the age of nano.
  27. Curcumin polymers as anticancer conjugates.

Brought to you by Mass Spectrum Botanicals

Curcuminoid Drug Delivery (Nootropic):

  1. Neuroprotective and neurorescue effects of a novel polymeric nanoparticle formulation of curcumin (NanoCurc™) in the neuronal cell culture and animal model: implications for Alzheimer’s disease.

Curcuminoid Drug Delivery (Oral Cancer):

  1. Effect of preparation techniques on the properties of curcumin liposomes: characterization of size, release and cytotoxicity on a squamous oral carcinoma cell line.
  2. Nitric oxide-mediated histone hyperacetylation in oral cancer: target for a water-soluble HAT inhibitor, CTK7A.

Curcuminoid Drug Delivery (Prostate Cancer):

  1. Curcumin and genistein coloaded nanostructured lipid carriers: in vitro digestion and antiprostate cancer activity.

Curcuminoid Drug Delivery (Skin Cancer):

  1. Development and characterization of eucalyptol microemulsions for topic delivery of curcumin.
  2. Structurally modified curcumin analogs inhibit STAT3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell lines.
  3. Distribution of polyphenols and a surfactant component in skin during Aerosol OT microemulsion-enhanced intradermal delivery.
  4. Design and evaluation of cyclodextrin-based delivery systems to incorporate poorly soluble curcumin analogs for the treatment of melanoma.
  5. Curcumin-loaded lipid and polymeric nanocapsules stabilized by nonionic surfactants: an in vitro and In vivo antitumor activity on B16-F10 melanoma and macrophage uptake comparative study.
  6. Development and characterization of eucalyptol microemulsions for topic delivery of curcumin.

Curcuminoid Drug Delivery (Throat Cancer):

  1. Design, synthesis and evaluation of novel PEGylated curcumin analogs as potent Nrf2 activators in human bronchial epithelial cells.

Synonyms:

Amomoum curcuma, anlatone (constituent), ar-tumerone, CUR, Curcuma , Curcuma aromatica , Curcuma aromatica salisbury, Curcuma domestica , Curcuma domestica valet, Curcuma longa , Curcuma longa Linn, Curcuma longa rhizoma, curcuma oil, curcumin, diferuloylmethane, E zhu, Gelbwurzel, gurkemeje, haldi, Haridra, Indian saffron, Indian yellow root, jiang huang, kunir, kunyit, Kurkumawurzelstock, kyoo, NT, number ten, Olena, radix zedoaria longa, rhizome de curcuma, safran des Indes, sesquiterpenoids, shati, tumeric, turmeric oil, turmeric root, tumerone (constituent), Ukon, yellowroot, zedoary, Zingiberaceae (family), zingiberene, Zitterwurze, turmeric, common turmeric, long turmeric, curcuma, safran des indes, kurkuma-gelbwurzel, gurkmeja, kurkum, geelwortel, acafrao-da-India, zholty imbir’, ukon, yu-chin, cago, rerega, haldi, kunyit, temu kunyit, ro miet, kunir, komeng, khi min, khmin khun, tius, lavar, tamaravirua, aruq as-suff, zard-cholic, dilaw, kalabaga, kunik, ango, ango hina, renga, re’a, avea, ago, tale’s, ena, khamin, khamin kaeng, khamin chan, nghe, nghe vang, uat kim, khuong hoang, co hem, co khan min, khinh luongl, Trumbo (Pakistan)

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Additional Information

Quantities & Prices

2 Live Rhizomes, 15 Live Rhizomes, 1 SFRBox Rhizomes, 1 MFRBox Rhizomes, 1 LFRBox Rhizomes, 1 Root + Black Pepper Combo, 1 Double Turmeric + Pepper Combo, One 6-10″ Live Plant, Five 6-10″ Live Plants, One 10-16″ Live Plant, One 20-30″ Live Plant, 50 Grams Turmeric Powder (Spice), 1 Lb. Turmeric Powder (Spice), 4 Lbs. Turmeric Powder (Spice), 25 Grams 98% Curcumin (YT Extract), 50 Grams 98% Curcumin (YT Extract), 100 Grams 98% Curcumin (YT Extract), 250 Grams 98% Curcumin (YT Extract), 500 Grams 98% Curcumin (YT Extract), 1KG 98% Curcumin (YT Extract), 25KG 98% Curcumin (YT Extract)


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